Glossary entry (derived from question below)
German term or phrase:
Masthormon
English translation:
fat-producing hormone (fat hormone)
Added to glossary by
Martina Kilgo
Jul 15, 2013 18:34
10 yrs ago
3 viewers *
German term
United States
If You Need Results
Native in: German 
, English
Works in: German to English, English to German
Masthormon
German to English
Medical
Medical (general)
Es geht hier um ein moegliches Medikament zur Behandlung von Tumorkachexien in Krebspatienten. Die Befragte sagt:
Mich wuerde natuerlich der Wirkmechanismus interessieren. Wenn wir ein Medikament wie Insulin haben, also ein "Masthormon"...
The only translation I could find was "GMO hormone" which basically means genetically modified organism. I am not really sure that I should use this translation.
Could it simply be translated with "fattening hormone" or something like that, or is there actually an English term for this?
Mich wuerde natuerlich der Wirkmechanismus interessieren. Wenn wir ein Medikament wie Insulin haben, also ein "Masthormon"...
The only translation I could find was "GMO hormone" which basically means genetically modified organism. I am not really sure that I should use this translation.
Could it simply be translated with "fattening hormone" or something like that, or is there actually an English term for this?
Proposed translations
(English)
References
| anabolic hormone / growth factor |
Gudrun Maydorn (X)
|
| feeding hormone? |
uyuni
|
Proposed translations
6 hrs
Michael Martin, MA
United States
United States
Native in German
&
English
Works in field
United States
Creativity wins in the long run
Native in: German (Variant: Germany) , English (Variant: US)
Works in: German to English
Related KudoZ points
:
159
Selected
fat-producing hormone (fat hormone)
See link below:
"If all the glycogen storage areas are filled, and there is still more glucose in the blood beyond that which the body needs to function, insulin will convert the excess to fatty tissue called triglyceride, which we carry on our bodies as the main chemical constituent of adipose tissue – the stuff you're reading this book to get rid of. That's why insulin has been called "the fat-producing hormone."
"If all the glycogen storage areas are filled, and there is still more glucose in the blood beyond that which the body needs to function, insulin will convert the excess to fatty tissue called triglyceride, which we carry on our bodies as the main chemical constituent of adipose tissue – the stuff you're reading this book to get rid of. That's why insulin has been called "the fat-producing hormone."
Note from asker:
| Thank you Michael :) |
4 KudoZ points awarded for this answer.
Comment: "Thank you Michael, I decided that your recommendation fits best :)"
14 mins
Stefanie Reinhold
United States
United States
Native in German
Specializes in field
United States
Your German language connection!
Native in: German (Variant: Germany) 
Works in: English to German, German to English
Related KudoZ points
:
4
obesity hormone
Since "Masthormon" is not really a scientific term but a construction used to express a certain effect of insulin, I would vote for obesity hormone.
Note from asker:
| Thank you Stefanie :) |
2 hrs
Frauke Bruno, PhD
United States
United States
Native in German
&
English
Specializes in field
United States
specialized: patents/litigation, biology
Native in: English , German
Works in: German to English
growth factor
'Masthormone' werden in der Tierzucht (in der USA) zum "Masten" verwendet, und sind zB estrogen oder insulin, die alle zu den Growth Factor Receptor Hormone gehoeren.
Ich galube eher nicht, dass hier ein Zusammenhang mit obesity besteht
Ich galube eher nicht, dass hier ein Zusammenhang mit obesity besteht
Note from asker:
| Thank Frauke :) |
+1
14 hrs
Marga Shaw
United Kingdom
United Kingdom
Native in German
Specializes in field
United Kingdom
Language matters
Native in: German (Variants: Austrian, Germany, Swiss)
Works in: English to German, German to English
Related KudoZ points
:
700
fattening hormone
as Martina already suggested.
Neither "Masthormon" nor "fattening hormone" are scientific terms. However, they seem to be frequently found in association with insulin, e.g. insulin is the fattening hormone of the body.
According to xxx, insulin is the <b|>“fattening” hormone that is largely responsible for the current obesity epidemic. By ignoring the main function of insulin, to drive glucose into muscle cells so that they can use the glucose to make glycogen, Taubes makes the case that obesity is a matter of conspiring hormones and that that endocrinologists have known for 50 years that “insulin regulates fat accumulation.
http://www.mccarbthyism.com/Blog.html?entry=the-new-mccarbth...
After the discovery of insulin in 1921, the potential role of insulin as a fattening hormone would become a long'running controversy. (p. 378)
http://books.google.co.uk/books?id=GIdodweSSE4C&pg=PA378&lpg...
Firstly, insulin puts on weight. Its purpose is to take energy out of the bloodstream and store it as fat — the very thing that conventional treatment is aimed at stopping. For this reason:
Insulin is the most fattening hormone.
Diabetics who have to inject insulin find it almost impossible to lose weight.
http://www.second-opinions.co.uk/diabetes-3.html#.UeTynqyZG4...
From the above follows:
The present study was designed to evaluate whether daily insulin treatment for weight-losing cancer patients attenuates the progression of cancer cachexia and improves metabolism and physical functioning in palliative care.
http://www.ncbi.nlm.nih.gov/pubmed/17473202
However, due to differences in the models utilized, results are mixed with regards to the effectiveness of insulin treatment in cancer cachexia and may be related to the degree of insulin sensitivity exhibited. Animals implanted with Walker 256 tumors show improvement in cachectic symptoms with daily insulin administration, including increased body weight and decreased tumor mass [42–44]. Similar results have been observed in other cancer cachexia models [45, 46]. In contrast, treatment with exogenous insulin failed to have any effect on cachexia-related parameters in mice inoculated with colon-26 adenocarcinoma [47]. It is possible that insulin resistance is more complete in these animals than in other models. This is supported by the fact that the administration of insulin also had no effect on blood glucose levels in the colon-26 tumor-bearing animals.
http://www.jcsm.info/index.php/en/?option=com_content&view=a...
A recent study of <c>insulin treatment of cancer cachexia also showed patients increased whole body fat, with no effect on fat-free lean tissue.
http://physrev.physiology.org/content/89/2/381.full.pdf
A number of other drugs have been evaluated in a pilot fashion for the treatment of cancer anorexia and
cachexia. They include branched-chain amino acids, thalidomide (Thalomid), metoclopramide, oxandrolone (Oxandrin), insulin, and adenosine triphosphate. It is hoped that new information will be available in the near future to shed light on the possible therapeutic roles of these agents.
https://www.mims.com/resources/module/customcontent/OTHERS/c...
Insulin treatment in tumor cachexia has ben investigated in various clinical trials. Its value seems still to be very controversial. I think that Martina's question was about if the fattening hormone insulin is/would be beneficial in the treatment of tumor cachexia or similar.
Neither "Masthormon" nor "fattening hormone" are scientific terms. However, they seem to be frequently found in association with insulin, e.g. insulin is the fattening hormone of the body.
According to xxx, insulin is the <b|>“fattening” hormone that is largely responsible for the current obesity epidemic. By ignoring the main function of insulin, to drive glucose into muscle cells so that they can use the glucose to make glycogen, Taubes makes the case that obesity is a matter of conspiring hormones and that that endocrinologists have known for 50 years that “insulin regulates fat accumulation.
http://www.mccarbthyism.com/Blog.html?entry=the-new-mccarbth...
After the discovery of insulin in 1921, the potential role of insulin as a fattening hormone would become a long'running controversy. (p. 378)
http://books.google.co.uk/books?id=GIdodweSSE4C&pg=PA378&lpg...
Firstly, insulin puts on weight. Its purpose is to take energy out of the bloodstream and store it as fat — the very thing that conventional treatment is aimed at stopping. For this reason:
Insulin is the most fattening hormone.
Diabetics who have to inject insulin find it almost impossible to lose weight.
http://www.second-opinions.co.uk/diabetes-3.html#.UeTynqyZG4...
From the above follows:
The present study was designed to evaluate whether daily insulin treatment for weight-losing cancer patients attenuates the progression of cancer cachexia and improves metabolism and physical functioning in palliative care.
http://www.ncbi.nlm.nih.gov/pubmed/17473202
However, due to differences in the models utilized, results are mixed with regards to the effectiveness of insulin treatment in cancer cachexia and may be related to the degree of insulin sensitivity exhibited. Animals implanted with Walker 256 tumors show improvement in cachectic symptoms with daily insulin administration, including increased body weight and decreased tumor mass [42–44]. Similar results have been observed in other cancer cachexia models [45, 46]. In contrast, treatment with exogenous insulin failed to have any effect on cachexia-related parameters in mice inoculated with colon-26 adenocarcinoma [47]. It is possible that insulin resistance is more complete in these animals than in other models. This is supported by the fact that the administration of insulin also had no effect on blood glucose levels in the colon-26 tumor-bearing animals.
http://www.jcsm.info/index.php/en/?option=com_content&view=a...
A recent study of <c>insulin treatment of cancer cachexia also showed patients increased whole body fat, with no effect on fat-free lean tissue.
http://physrev.physiology.org/content/89/2/381.full.pdf
A number of other drugs have been evaluated in a pilot fashion for the treatment of cancer anorexia and
cachexia. They include branched-chain amino acids, thalidomide (Thalomid), metoclopramide, oxandrolone (Oxandrin), insulin, and adenosine triphosphate. It is hoped that new information will be available in the near future to shed light on the possible therapeutic roles of these agents.
https://www.mims.com/resources/module/customcontent/OTHERS/c...
Insulin treatment in tumor cachexia has ben investigated in various clinical trials. Its value seems still to be very controversial. I think that Martina's question was about if the fattening hormone insulin is/would be beneficial in the treatment of tumor cachexia or similar.
Peer comment(s):
| agree |
Harald Moelzer (medical-translator)
: best choice here, as can be seen from your refs
1 day 22 hrs
|
|
Many thanks, Harald! :-)
|
+2
16 hrs
anabolic hormone
see reference comment
19 hrs
Alexandra Lemonidis
United Kingdom
United Kingdom
Native in English
Specializes in field
United Kingdom
Related KudoZ points
:
4
weight-gain hormone
There are a couple of websites (admittedly less scientific) that use this term:
http://blogs.prevention.com/prevention-news/2011/10/05/daily...
http://forums.steroid.com/anabolic-steroids-questions-answer...
http://www.naturalnews.com/039758_meditation_chronic_stress_...
http://blogs.prevention.com/prevention-news/2011/10/05/daily...
http://forums.steroid.com/anabolic-steroids-questions-answer...
http://www.naturalnews.com/039758_meditation_chronic_stress_...
Reference comments
11 hrs
Reference:
anabolic hormone / growth factor
What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated?
...
The cancer cachexia syndrome is characterized by anorexia, weight loss with muscle wasting and increased energy expenditure. It is associated with increased morbidity and mortality, but its aetiology is poorly understood and no effective therapeutic intervention is available. It may result from an imbalance between the activity or effect of anabolic and catabolic hormones, mediated by the inflammatory cytokines.
http://eprints.ucl.ac.uk/28146/
The European Palliative Care Research Collaborative (EPCRC) defines cancer-related cachexia thus:
A multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be reversed by conventional nutritional support and leads to progressive functional impairment.
....
Hypercaloric feeding has repeatedly been shown as ineffective in increasing lean mass.
...
Insulin: insulin resistance is observed in cachexia. The possibility of utilising the insulin signalling system is currently being explored.
http://www.patient.co.uk/doctor/cachexia
...
The cancer cachexia syndrome is characterized by anorexia, weight loss with muscle wasting and increased energy expenditure. It is associated with increased morbidity and mortality, but its aetiology is poorly understood and no effective therapeutic intervention is available. It may result from an imbalance between the activity or effect of anabolic and catabolic hormones, mediated by the inflammatory cytokines.
http://eprints.ucl.ac.uk/28146/
The European Palliative Care Research Collaborative (EPCRC) defines cancer-related cachexia thus:
A multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be reversed by conventional nutritional support and leads to progressive functional impairment.
....
Hypercaloric feeding has repeatedly been shown as ineffective in increasing lean mass.
...
Insulin: insulin resistance is observed in cachexia. The possibility of utilising the insulin signalling system is currently being explored.
http://www.patient.co.uk/doctor/cachexia
Peer comments on this reference comment:
| agree |
Nicole Schnell
9 mins
|
|
thanks Nicole
|
|
| agree |
Anne Schulz
: "anabolic hormone" trifft es, finde ich, gut
41 mins
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danke, Anne
|
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| agree |
roguestate
4 hrs
|
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thanks roguestate
|
15 hrs
Reference:
feeding hormone?
The feeding hormone ghrelin modulates the ability of rewarding food to evoke dopamine release within the brain
http://www.ssib.org/web/index.php?page=press&release=2011-3
Ghrelin (Akronym, engl. Growth Hormone Release Inducing „Wachstumshormonfreisetzung einleitend“) ist ein appetitanregendes Hormon, welches in der Magenschleimhaut produziert wird. Neben der Appetitanregung hat das Hormon eine Reihe anderer Wirkungen...Möglicherweise spielt es eine Rolle bei der Entstehung von Adipositas.
http://de.wikipedia.org/wiki/Ghrelin
http://www.ssib.org/web/index.php?page=press&release=2011-3
Ghrelin (Akronym, engl. Growth Hormone Release Inducing „Wachstumshormonfreisetzung einleitend“) ist ein appetitanregendes Hormon, welches in der Magenschleimhaut produziert wird. Neben der Appetitanregung hat das Hormon eine Reihe anderer Wirkungen...Möglicherweise spielt es eine Rolle bei der Entstehung von Adipositas.
http://de.wikipedia.org/wiki/Ghrelin
Discussion
Der Einsatz von Insulin, ein Masthormon, ist ein noch relativ neuer Ansatz zur Behandlung von Tumorkachexien, der davon ausgeht, dass Insulin zur Gewichtszunahme führt (wird z. B. auch beim Mästen von Tieren eingesetzt) (siehe auch meine Antwort unten). Diese Behandlung schient übrigens recht umstritten zu sein.
In einer Antort wäre es m. E. deshalb erstrebenswert bei dem Begriff Insulin, ein Masthormon, zu bleiben und ihn nicht mit anabolischem Hormon/Steroid und Wachstumshormon zu vermischen, obwohl Assoziationen bestehen.
Insulin ist ein im Pankreas gebildetes Peptidhormon, das die Aufnahme von Glucose in Körperzellen reguliert und noch viele andere Funktionen hat. Es ist auch ein Hormon mit anabolischer Eigenschaft (Muskelaufbau).
Anabole Steroide/Hormone stimulieren die Proteinsynthese, Muskelaufbau und Insulin.
Das Wachstumshormon (somatrope Hormon) ist ein im Hypophysenvorderlappen gebildetes Peptidhormon, welches das Wachstum und den Stoffwechsel beeinflusst.
http://de.wikipedia.org/wiki/Tumorkachexie