David Williams (asker) May 25, 2012:

I'd like to give you the points, SJLD

uyuni May 23, 2012:

w/ Johanna, Anne & SJLD why not post is an answer (detection/detecting...)?

David Williams (asker) May 23, 2012:

Thanks for confirming that, SJLD! That sounds excellent to me.

SJLD May 23, 2012:

In patients with metastatic breast cancer, the prognostic relevance/value of detecting circulating tumour cells in (peripheral) blood has already been demonstrated.

I would drop "corresponding".
As I read it the discussion is about whether the patient should be tested for CTCs - is it a worthwhile test, does it add any prognostic information?

David Williams (asker) May 23, 2012:

So you would say "the prognostic relevance of a corresponding detection in the blood"?

Anne Schulz May 23, 2012:

Agree with Johanna Nachweis = detection

David Williams (asker) May 23, 2012:

In this context I think I'll follow the lead of the IMM's wording:
"the prognostic relevance of circulating tumour cells in the blood"

David Williams (asker) May 23, 2012:

The previous sentence is: In diesem Zusammenhang wird bei verschiedenen Krebserkrankungen die klinische Signifikanz zirkulierender Tumorzellen intensiv diskutiert.

My translation:

There is intense debate in the field concerning the clinical significance of circulating tumour cells with relation to various types of cancer.

So it is the same German sentence as the one you posted, although it looks like it was definitely translated into English by a German at the IMM.

Alison MacG May 23, 2012:

The previous sentence would have been helpful As you have not disguised your text, I am assuming that it is OK to post this.
Die kaum glaubliche Suche nach einzelnen Krebszellen
(...)
In diesem Zusammenhang wird bei verschiedenen Krebserkrankungen die klinische Signifikanz zirkulierender Tumorzellen intensiv diskutiert.
http://www.medica.de/cgi-bin/md_medica/custom/pub/content.cg...

I have also found an existing English translation for your reference:
In this regard, the clinical significance of circulating tumor cells (CTCs) is discussed for different types of cancer. For metastasized patients with breast cancer the prognostic relevance of CTC detection in peripheral blood was already demonstrated.
http://www.imm-mainz.de/727.html

Berk Ozen May 23, 2012:

The evidence or proof that may carry a prognostic value for breast metastasis (elevation of hormone levels, etc.), let's say the patient had lung cancer before metastasis, could have been demonstrated by prognostic blood detection tests earlier, and appropriate preventive treatment could be applied.

Judith Shiozawa (X) May 23, 2012:

Example of the use of "marker" "Tumor markers shown to have prognostic value but not used routinely ...."
http://breast-cancer-research.com/content/6/3/109

ingeving (X) May 23, 2012:

In my opinion the words "entsprechenden Nachweis" are important here.
it has already been possible to demonstrate the prognostic relevance of the corresponding proof in the blood.

Wendy Streitparth May 23, 2012:

And I think "evidence in the blood" is acceptable.

Wendy Streitparth May 23, 2012:

or traces in the blood?

Dr. Johanna Schmitt May 23, 2012:

Was genau wird denn im Blut nachgewiesen? Might "detection in the blood" be another option?

Judith Shiozawa (X) May 23, 2012:

The word "marker" is what first comes to my mind.

David Williams (asker) May 23, 2012:

I'm thinking along the lines of For patients with metastatic breast cancer (mammary carcinoma) it has already been possible to demonstrate the prognostic relevance of such evidence/proof in the blood.