Glossary entry (derived from question below)
English term or phrase:
backfill patient
Spanish translation:
Paciente con dosis inferior a las asignadas durante el estudio/al intervalo manejado en el estudio
Added to glossary by
David Balayla
Apr 20, 2022 09:33
2 yrs ago
43 viewers *
English term
Spain
Translation & Communication
Native in: English (Variant: British) 
, Spanish (Variant: Standard-Spain) , Catalan (Variants: Oriental, Valencian, Central, Western)
Works in: English to Spanish, Spanish to English, English to Catalan, and 5 more.
"backfill patient"
English to Spanish
Medical
Medical: Health Care
Clinical trial (patient-facing)
Proposed translations
(Spanish)
| 4 | Paciente con dosis inferior *a las asignadas durante el estudio/al intervalo manejado en el estudio* |
abe(L)solano
|
References
| Backfill-Oncology trials |
abe(L)solano
|
| see |
liz askew
|
Proposed translations
34 mins
abe(L)solano
France
France
Native in Spanish
Specializes in field
France
PhD & Pharmacist. Life Sciences.
Native in: Spanish (Variants: Standard-Spain, Latin American) 
Works in: English to Spanish, French to Spanish
Related KudoZ points
:
100
English term (edited):
backfill patient
Selected
Paciente con dosis inferior *a las asignadas durante el estudio/al intervalo manejado en el estudio*
By your note I guess this fits into your document's context.
See ref and
https://si.biostat.washington.edu/sites/default/files/module...
“Backfill” of lower dose levels: enroll
additional patients at lower doses during
escalation to establish dose-toxicity and dose-response curves"
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Note added at 40 minutos (2022-04-20 10:14:03 GMT)
--------------------------------------------------
Maybe this other wording can be also understood by a potential participant:
"Paciente con dosis inferior a cualquier dosis (prevista) durante el estudio"
You really need to explain the concept in Spanish.
See ref and
https://si.biostat.washington.edu/sites/default/files/module...
“Backfill” of lower dose levels: enroll
additional patients at lower doses during
escalation to establish dose-toxicity and dose-response curves"
--------------------------------------------------
Note added at 40 minutos (2022-04-20 10:14:03 GMT)
--------------------------------------------------
Maybe this other wording can be also understood by a potential participant:
"Paciente con dosis inferior a cualquier dosis (prevista) durante el estudio"
You really need to explain the concept in Spanish.
4 KudoZ points awarded for this answer.
Comment: "Thanks Abel, spot on!"
Reference comments
24 mins
abe(L)solano
France
France
Native in Spanish
Specializes in field
France
PhD & Pharmacist. Life Sciences.
Native in: Spanish (Variants: Standard-Spain, Latin American)
Works in: English to Spanish, French to Spanish
Related KudoZ points
:
100
Reference:
Backfill-Oncology trials
You don't give any clue but maybe this may help.
https://pubmed.ncbi.nlm.nih.gov/34743987/#:~:text=Abstract,w...
The use of backfill in early phase dose-finding trials is a relatively recent practice. It consists of assigning patients to dose levels below the level where the study is at.
Would be simply
"Paciente con dosis inferior *a las asignadas durante el estudio/al intervalo manejado en el estudio*"
https://pubmed.ncbi.nlm.nih.gov/34743987/#:~:text=Abstract,w...
The use of backfill in early phase dose-finding trials is a relatively recent practice. It consists of assigning patients to dose levels below the level where the study is at.
Would be simply
"Paciente con dosis inferior *a las asignadas durante el estudio/al intervalo manejado en el estudio*"
Note from asker:
| Yes! Many thanks for this. |
1 hr
Reference:
see
Note from asker:
| Thanks Liz. Yes, it seems this answer missed the main point, which is that new enrollment is assigned lower dose levels (than those in the initial design of the study). |
Peer comments on this reference comment:
| neutral |
abe(L)solano
: Didn't see this Proz entry but no doubt they skipped the main point: enrollment is restricted for lower dose levels.
4 hrs
|
Discussion
No tengo claro que la referencia a tratamientos experimentales con dosis inferiores a las del estudio principal deba inferirse del concepto de backfill patient/cohort -que sin otro contexto trasladaría la idea de pacientes adicionales (o cohortes adicionales/suplementarias).
https://www.proz.com/siterules/kudoz_general/1.4#1.4