Glossary entry (derived from question below)
German term or phrase:
PT-Gesichtsödem
English translation:
PT–face edema
Added to glossary by
Anne Schulz
Dec 16, 2019 01:34
4 yrs ago
5 viewers *
German term
Canada
Quality, Accuracy and Experience
Native in: English (Variants: US, Canadian) 
, Tagalog
Works in: German to English, Russian to English, French to English, and 4 more.
PT-Gesichtsödem
German to English
Medical
Medical: Pharmaceuticals
Drug side effects
This is one of the side effects of cisplatin. Can't seen to find out what PT stands for. I tried everything plausible that the https://www.medizinische-abkuerzungen.de site suggested but to no avail: perkutanes, partielles, post transfusionem...
Symptome die für anaphylaktoide Reaktionen berichtet wurden wie Gesichtsödem (PT-Gesichtsödem), Giemen, Bronchospasmus, Tachykardie und Hypotonie
Symptome die für anaphylaktoide Reaktionen berichtet wurden wie Gesichtsödem (PT-Gesichtsödem), Giemen, Bronchospasmus, Tachykardie und Hypotonie
Proposed translations
(English)
| 4 +4 | PT–facial edema |
Anne Schulz
|
| 1 -1 | Prothrombin Time |
Sarojini Seeneevassen
|
References
| Preferred Term |
Adam Dickinson
|
Change log
Dec 17, 2019 03:38: Anne Schulz Created KOG entry
Proposed translations
+4
7 hrs
Selected
PT–facial edema
I agree with Steffen about PT = Platin/platinum, even though no references can be found for "Platin-Gesichtsödem" or the like.
In the first place, however, "PT-Gesichtsödem" seems to be copied from the Cisplatin Fachinformation which in turn adopted "PT-Gesichtsödem" as a literal translation from the English summary of product characteristics ("PT–facial edema"), since the English SmPC is usually the "core document" in EMA marketing authorisation procedures.
See, for example https://www.medicines.org.uk/emc/product/3788/smpc
"Symptoms reported for anaphylactoid reaction such as facial oedema (PT–face oedema), wheezing, bronchospasm, tachycardia, and hypotension will be included in the parentheses for anaphylactoid reaction in the AE frequency table."
https://www.accord-healthcare.de/sites/default/files/2018-06...
"Für anaphylaktoide Reaktionen berichtete Symptome wie Gesichtsödem (PT-Gesichtsödem), pfeifendes Atmen, Bronchospasmus, Tachykardie und Hypotension werden in der UAW-Häufigkeitstabelle in Klammern für anaphylaktoide Reaktionen angegeben."
In the first place, however, "PT-Gesichtsödem" seems to be copied from the Cisplatin Fachinformation which in turn adopted "PT-Gesichtsödem" as a literal translation from the English summary of product characteristics ("PT–facial edema"), since the English SmPC is usually the "core document" in EMA marketing authorisation procedures.
See, for example https://www.medicines.org.uk/emc/product/3788/smpc
"Symptoms reported for anaphylactoid reaction such as facial oedema (PT–face oedema), wheezing, bronchospasm, tachycardia, and hypotension will be included in the parentheses for anaphylactoid reaction in the AE frequency table."
https://www.accord-healthcare.de/sites/default/files/2018-06...
"Für anaphylaktoide Reaktionen berichtete Symptome wie Gesichtsödem (PT-Gesichtsödem), pfeifendes Atmen, Bronchospasmus, Tachykardie und Hypotension werden in der UAW-Häufigkeitstabelle in Klammern für anaphylaktoide Reaktionen angegeben."
Note from asker:
| thanks Anne and Steffen, yes platinum is highly plausible because cisplatin contains platinum as one of its active ingredients, and my text is all about platinum side effects. I'll settle with PT-face edema since that's what you see in the literature anyway |
| I meant "PT–facial edema" |
Peer comment(s):
| agree |
Marga Shaw
: Anaphylactic-like reactions to cisplatin have been reported and include facial edema,www.omegalaboratory.com › index.php › download_file › view
21 mins
|
|
Danke Marga :-)
|
|
| agree |
Susanne Schiewe
: Das wird's wohl sein, ja.
27 mins
|
|
Danke Susanne – was immer es ist, "PT" ist wahrscheinlich "PT" ;-)
|
|
| agree |
Barbara Schmidt, M.A. (X)
: agree
31 mins
|
|
Danke Barbara :-)
|
|
| agree |
Steffen Walter
: Ja, wahrscheinlich. Seltsamerweise finden sich aber auch keine Treffer für "platininduziertes Gesichtsödem" und "therapieinduziertes Gesichtsödem". / Stimmt, wie ich oben schrieb: the joys of copy & paste ;-)
1 hr
|
|
Nach gefühlt 1000 übersetzten SPCs glaube ich nicht mehr, dass die Angaben darin immer sinnvoll und repräsentativ sind. Vielleicht ist es ein lokaler Ausdruck, den der SPC-Verfasser aufgeschnappt hat und der dann treulich immer weiter abgeschrieben wird?
|
4 KudoZ points awarded for this answer.
Comment: "Thank you everyone for your input! We could always rely on our Proz family for a lively elucidating debate"
-1
2 hrs
Sarojini Seeneevassen
Mauritius
Mauritius
Native in English
Mauritius
Native, my main target language
Native in: English
Works in: German to English, French to English, Creoles & Pidgins (French-based Other) to English
Prothrombin Time
It seems far-fetched but might help. I found PT as a blood clotting test in the following:
‘COUNT(REAC.PT)’
http://webcl5top.rz.uni-kiel.de/pharmacology/pvt/openvigil-c...
‘A prothrombin time (PT) is a test used to help detect and diagnose a bleeding disorder or excessive clotting disorder;’
https://labtestsonline.org/tests/prothrombin-time-and-intern...
--------------------------------------------------
Note added at 5 hrs (2019-12-16 06:57:38 GMT)
--------------------------------------------------
I think Adam is probably right with Preferred Term
‘COUNT(REAC.PT)’
http://webcl5top.rz.uni-kiel.de/pharmacology/pvt/openvigil-c...
‘A prothrombin time (PT) is a test used to help detect and diagnose a bleeding disorder or excessive clotting disorder;’
https://labtestsonline.org/tests/prothrombin-time-and-intern...
--------------------------------------------------
Note added at 5 hrs (2019-12-16 06:57:38 GMT)
--------------------------------------------------
I think Adam is probably right with Preferred Term
Reference comments
20 mins
Adam Dickinson
Canada
Canada
Native in English
Canada
Multilingual, versatile translator
Native in: English 
Works in: Spanish to English, French to English, German to English, and 1 more.
Reference:
Preferred Term
Not my area of expertise, so just posting this for reference.
I searched Ödem PT and found a number of lab reports where they use PTs to denote the preferred term for a given group of side effects. Here are a few references:
https://www.iqwig.de/download/A19-91_Pomalidomid_Addendum-zu...
"Auf Basis aller UEs unabhängig vom Schweregrad zeigt sich für die Endpunkte Katarakt (PT, UE), Obstipation (PT, UE), Stomatitis (PT, UE)"
(Elsewhere in the report, a note says that PT stands for Preferred Term, UE for unerwünschtes Ereignis)
https://ec.europa.eu/health/documents/community-register/201...
Abkürzungen: n = Anzahl der Patienten, PT = bevorzugte Bezeichnung (preferred term, PT).
https://www.g-ba.de/downloads/92-975-2442/2018-06-01_Nutzenb...
Glossary entry with PT=preferred term, also notes that Ödem is "zusammengesetzt aus mehrerem PT", so noting that some effects are catch-all terms.
Also, cool to see another translator in Toronto! Glad I'm not the only one working late on a Sunday :)
I searched Ödem PT and found a number of lab reports where they use PTs to denote the preferred term for a given group of side effects. Here are a few references:
https://www.iqwig.de/download/A19-91_Pomalidomid_Addendum-zu...
"Auf Basis aller UEs unabhängig vom Schweregrad zeigt sich für die Endpunkte Katarakt (PT, UE), Obstipation (PT, UE), Stomatitis (PT, UE)"
(Elsewhere in the report, a note says that PT stands for Preferred Term, UE for unerwünschtes Ereignis)
https://ec.europa.eu/health/documents/community-register/201...
Abkürzungen: n = Anzahl der Patienten, PT = bevorzugte Bezeichnung (preferred term, PT).
https://www.g-ba.de/downloads/92-975-2442/2018-06-01_Nutzenb...
Glossary entry with PT=preferred term, also notes that Ödem is "zusammengesetzt aus mehrerem PT", so noting that some effects are catch-all terms.
Also, cool to see another translator in Toronto! Glad I'm not the only one working late on a Sunday :)
Note from asker:
| Thanks Adam/Kim! I'll look into "preferred term" |
Discussion
In any case, I'd seriously consider dropping the hyphen--unless you know someone whose edema was caused by their platinum face (1st option w/ hyphen) or a beauty treatment ("facial" option w/ hyphen).
[Or make a translator's note.]
Best of luck!
http://www.bccancer.bc.ca/drug-database-site/Drug Index/Cisp...
Stammt von 2016 und dort steht nichts in Klammern; USA hat MedDRA seit ca. 2018, wenn ich das richtig las; Kanada keine Ahnung.
Ich bin nun kein Medizinübersetzer und halte ich bei solchen Fragen normalerweise raus. Im juristischen Sinne, um den es im Endeffekt bei solchen Angaben geht, sehe ich allerdings keinerlei Nutzen darin, eine Nebenwirkung so in der Klassifikation zu beschränken, gerade in Nordamerika, wo doch noch mehr Leute als in Deutschland klagen =)
Beste Grüße
Marcus, have you got any chance to ask your client regarding this question?
https://www.worldallergy.org/ask-the-expert/questions/anaphy...
In this case, all of the adverse effects described must be related to cisplatinum, no?
And even though I get your point, I don't understand Anne's or Marga's reasoning. If this is indeed platinum-induced (which is what I'd prefer as a term; I don't know what a platinum face edema is supposed to be), the question remains why, from all those anaphylactoid reactions to a platinum derivative, the edema is the only one for which PT is added. To me, this makes it as plausible as the other suggestion, as facial edema was the term used but face (o)edema is the standard MedDRA term. Maybe someone should call the manufacturer =)
Best wishes and have a great Monday, all of you
The jury's still out on this question, though - I'm not sure either what PT (hyphenated) means here. The MedDRA reference/interpretation (PT = preferred term) may or may not be applicable in this case.
"She still has some residual facial edema, and not sure if the rash are Rosacea (preferred term: Rosacea). The outcome of the events not sure if the rash are rosacea, facial edema and with worsening rash on face was unknown. The events not sure if the rash are rosacea, facial edema and with worsening rash were considered serious with seriousness criteria of important medical event."
http://www.medalerts.org/vaersdb/findfield.php?EVENTS=on&PAG...
Not that this makes much sense to me, but they seem to repeat the same term if necessary. What does look odd, though, I agree, is that there's a hyphen between both words (in German) and that they only use PT for one of these adverse effects.
Best wishes
"The term used to describe an adverse event in the Database of Adverse Event Notifications - medicines is the MedDRA 'preferred term', which describes a single medical concept.
Each MedDRA system organ class has a number of MedDRA preferred terms associated with it. For example, the system organ class 'cardiac disorders' includes (among others) the following preferred terms:
angina
cardiac arrest
myocardial infarction
palpitations."
https://www.tga.gov.au/medical-dictionary-regulatory-activit...
From what I've found, the use of MedDRA terminology is mandatory in Europe and Japan and I think it's required in the States now, too. Not sure about Canada. What you could do is put "MedDRA preferred term" in parenthesis and use face edema, or oedema (two MedDRA entries, it seems), as Kim suggested (can't be 100% sure, but I believe it's correct).
Some MedDRA examples can be found at https://ora.ox.ac.uk/objects/uuid:7f9c9703-df1b-4787-ba58-21...
Best
"Symptoms reported for anaphylactoid reactions such as facial edema (preferred term), wheezing, bronchospasm, tachycardia and hypotension"
"Für anaphylaktoide Reaktionen berichtete Symptome wie Gesichtsödem (PT-Gesichtsödem), pfeifendes Atmen, Bronchospasmus, Tachykardie und Hypotension werden in der UAW-Häufigkeitstabelle in Klammern für anaphylaktoide Reaktionen angegeben."
https://www.accord-healthcare.de/sites/default/files/2018-06...
If you look for UAW, i.e., side effects, on Canadian pages you'll get to this document describing the effects of Cisplatin: http://www.bccancer.bc.ca/drug-database-site/Drug Index/Cisp...
On p. 6, it says: "Sensitivity reactions can include anaphylactoid reactions consisting of facial edema, flushing, wheezing or respiratory difficulties, tachycardia, and hypotension"
Seems you don't need it; if "facial edema" is good enough for the British Columbian government, it should be good enough for this manual.
Just my two cents, though; I'm not a doctor.
Best
Symptoms reported for anaphylactoid reactions such as facial edema (preferred term: facial edema), wheezing, bronchospasm, tachycardia and hypotension
https://ec.europa.eu/health/documents/community-register/201...
Die am häufigsten berichteten bevorzugten Begriffe (PTs, preferred term) waren Herpes zoster, oraler Herpes und Herpes simplex. https://ec.europa.eu/health/documents/community-register/201...