Mar 5, 2020 04:44
4 yrs ago
20 viewers *
English term
Brazil
Medicine and Nursing specialist
Native in: Portuguese (Variant: Brazilian) 
Works in: English to Portuguese, Portuguese to English
unchanged parent enzalutamide
English to Portuguese
Medical
Medical: Cardiology
Medicina - oncologia
A trace amount of unchanged parent enzalutamide was excreted in urine. N-Desmethyl enzalutamide was too low to quantitate in urine by LC–MS/MS.
Não consigo saber o q seria parent. Não encontro em nenhum texto científico em português, mas isso aparece em inglês. Podem ajudar?
Onrigada
Não consigo saber o q seria parent. Não encontro em nenhum texto científico em português, mas isso aparece em inglês. Podem ajudar?
Onrigada
Proposed translations
(Portuguese)
| 3 +2 | enzalutamida original |
Lucas Maciel
|
Proposed translations
+2
5 hrs
Lucas Maciel
Brazil
Brazil
Native in Portuguese
Brazil
Accuracy in subtitling
Native in: Portuguese (Variant: Brazilian)
Works in: English to Portuguese, Portuguese to English, Portuguese, and 1 more.
Related KudoZ points
:
4
Selected
enzalutamida original
Com a explicação da Marjolein, acredito que o termo se refira ao medicamento em seu estado original, sem modificações.
Peer comment(s):
| agree |
Clauwolf
: ... inalterada
1 hr
|
| agree |
Mario Freitas
: ... inalterada II
4 hrs
|
|
Perfeito!
|
4 KudoZ points awarded for this answer.
Discussion
See https://toxtutor.nlm.nih.gov/12-001.html
"Detoxification occurs when biotransformation results in metabolites of lower toxicity. In many cases, however, the metabolites are more toxic than the parent substance, a process called bioactivation."
or
https://www.ncbi.nlm.nih.gov/pubmed/2388874
Allopurinol and caffeine have been used to measure metabolite formation followed by renal elimination of both parent substance and metabolite.
Google "parent substance" for more examples (or try a combination, eg. "parent substance" with "metabolized").