split family (RTKs)
| 15:07 Oct 29, 2020 |
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| English to Polish translations [PRO] Medical - Medical (general) | |||||||
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| the TAM family of receptor tyrosine kinases (RTKs) |
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Reference comments
8 hrs |
| Reference: the TAM family of receptor tyrosine kinases (RTKs) Reference information: Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs) characterized by a conserved sequence within the kinase domain and adhesion molecule-like extracellular domains. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133732/ -------------------------------------------------- Note added at 9 hrs (2020-10-30 00:08:01 GMT) -------------------------------------------------- Background 1. Modified Toxicity Probability Interval Design: A Safer and More Reliable Method than the 3+3 Design for Practical Phase I Trials, 2013 Journal of Clinical Oncology 31:1785-1791. • MGCD516 (Sitravatinib) is an oral drug that inhibits a spectrum of related RTKs including: • TAM family (Axl and MERTK) and split family RTKs (VEGFR2 and PDGFRA): - https://www.mirati.com/wp-content/uploads/2019/10/20160603_A... |
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