Apr 25, 2018 12:37
6 yrs ago
44 viewers *
English term
Connecting the world
Native in: Spanish 
Works in: English to Spanish, Italian to Spanish
\"target engagement\"
English to Spanish
Medical
Medical: Pharmaceuticals
Hello everybody. It seems I am stuck with this translation. It is a research study on some drugs to help cure/prevent heart disease.
How would you translate "target engagement" here?:
These projects would be for the purpose of analysis of these additional exploratory protein biomarkers related to modulation of heart function and target engagement in heart failure.
Thank you!
How would you translate "target engagement" here?:
These projects would be for the purpose of analysis of these additional exploratory protein biomarkers related to modulation of heart function and target engagement in heart failure.
Thank you!
Proposed translations
(Spanish)
| 3 | uniòn a tejido diana/uniòn a diana |
George Simon
|
| 3 | interacción con moléculas diana |
Chema Nieto Castañón
|
Proposed translations
31 mins
George Simon
Hungary
Hungary
Native in English
&
Spanish
Specializes in field
Hungary
Medical Doctor / Linguist
Native in: Spanish 
, English (Variant: US)
Works in: Spanish to English, English to Spanish
Related KudoZ points
:
15
Selected
uniòn a tejido diana/uniòn a diana
From the context given it seems to me that it refers to protein biomarkers which engage or unite with their target in the presence of heart failure. Wether the target is a cell that has been compromised due to heart failure or a part of the cell structure is beyond the context.
4 KudoZ points awarded for this answer.
Comment: "Muchas gracias :-D"
2 days 1 hr
Chema Nieto Castañón
Spain
Spain
Native in Spanish
Specializes in field
Spain
Psychologist & Emergency Physician
Native in: Spanish (Variant: Standard-Spain)
Works in: English to Spanish
Related KudoZ points
:
553
interacción con moléculas diana
Target engagement, en este contexto, parece constituir una expresión ad hoc en referencia a la interacción de determinadas moléculas con objetivos o dianas proteicas en organismos vivos.
Por ejemplo,
Alternative assays must be enlisted to confirm that a small molecule interacts with its intended protein target in a living system, a parameter that is referred to as target engagement.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004587/
Así, por ejemplo,
... con el propósito de analizar estos biomarcadores proteicos [¿exploratorios? No estoy seguro de a qué se refiere exploratory aquí para plantear una traducción] adicionales relacionados con la modulación de la función cardíaca y con su interacción con moléculas diana en la insuficiencia cardíaca.
Por ejemplo,
Alternative assays must be enlisted to confirm that a small molecule interacts with its intended protein target in a living system, a parameter that is referred to as target engagement.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004587/
Así, por ejemplo,
... con el propósito de analizar estos biomarcadores proteicos [¿exploratorios? No estoy seguro de a qué se refiere exploratory aquí para plantear una traducción] adicionales relacionados con la modulación de la función cardíaca y con su interacción con moléculas diana en la insuficiencia cardíaca.
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