terén MLD
English translation: Metachromatic leukodystrophy
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| 19:13 Nov 20, 2012 |
| Czech to English translations [PRO] Medical - Medical (general) | |||||||
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|  Selected response from: Karel Machala Czech Republic Local time: 06:52 | ||||||
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| 4 +1 | Metachromatic leukodystrophy |
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| 3 | Metachromatic leukodystrophy (MLD) |
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Answers
8 mins confidence: 
peer agreement (net): +1
peer agreement (net): +1Metachromatic leukodystrophy Explanation: MLD - Metachromatic leukodystrophy terén MLD - MLD terrain Reference: http://en.wikipedia.org/wiki/Metachromatic_leukodystrophy |
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11 mins confidence:
Metachromatic leukodystrophy (MLD) Explanation: Metachromatic leukodystrophy (MLD) is an autosomal recessive condition presenting with progressive psychiatric, cognitive, and pyramidal features. Peripheral nerve demyelination is frequently found. The MRI changes have a posterior predominance and subcortical pattern. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a deficiency of the catabolic enzyme arylsulfatase A. Inheritance of the disease is autosomal recessive (1). It is known as the most common hereditary leukodystrophy, with a prevalence of one in 100 000 newborns (2). Deficiency of arylsulfatase A results in accumulation of a metachromatic lipid material, galactosylceramide sulfatide, in the white matter of the peripheral and central nervous system (2), which undergoes symmetric demyelination with initial sparing of the subcortical U fibers (3). Many magnetic resonance (MR) imaging features of MLD have been described, including symmetric confluent demyelination of the periventricular white matter and centrum semiovale with sparing of the subcortical arcuate fibers, frontal predominance and frontooccipital progression of demyelination, subcortical white matter involvement with corticosubcortical atrophy in the later stage, low signal intensity in the thalami on T2-weighted images, involvement of the cerebellar white matter, and absence of contrast enhancement of the lesion (1–8). |
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