replicate standard
| 17:10 Dec 21, 2023 |
| English to Russian translations [PRO] Tech/Engineering - Chemistry; Chem Sci/Eng / Chromatography | |||||
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| Replicates in Analytical Methods - When and How Many? |
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| Discussion entries: 4 | |
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Answers
9 hrs confidence: 
peer agreement (net): +1
peer agreement (net): +1* Explanation: измерение (разведений) стандартного раствора в нескольких повторностях https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&c... Следует использовать, по меньшей мере, 6 градуировочных стандартов в не менее чем двух повторностях. Линейность, точность 36–48 проб (6 уровней концентрации, 6–8 повторных анализов на каждом уровне, кроме того, 20 образцов для анализа помех) -------------------------------------------------- Note added at 9 hrs (2023-12-22 02:51:55 GMT) -------------------------------------------------- https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&c... -------------------------------------------------- Note added at 9 hrs (2023-12-22 02:53:45 GMT) -------------------------------------------------- Не та ссылка на второй фрагмент, надо https://www.unodc.org/documents/scientific/validation-R.pdf -------------------------------------------------- Note added at 21 hrs (2023-12-22 14:38:48 GMT) -------------------------------------------------- Все вопросы - к автору оригинала https://www.shimadzu.eu/sites/shimadzu.seg/files/shimadzu_ap... Calibration over the target concentration range is linear on both detectors, and precision is demonstrated below 2% for analysis of six replicate standards at the concentration range of interest -------------------------------------------------- Note added at 21 hrs (2023-12-22 15:06:07 GMT) -------------------------------------------------- https://www.jsmcentral.org/sm-chromatography/fulltext_acst-v... Three replicate standards per concentration level were prepared and processed. Three measurements of each extract were performed on the UHPLC System. The linearity range covers sub-therapeutic, therapeutic and supra-therapeutic (toxic) levels |
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Reference comments
1 day 17 hrs |
| Reference: Replicates in Analytical Methods - When and How Many? Reference information: Do you prepare your samples/standards in duplicate without really thinking about it? If challenged on why, would your answer be something like, "it's good practice, isn't it?" The use of replicates in analytical procedures is commonplace but it is important to understand why you are doing it and also what the results are telling you. There are different types of replicates in analytical methods, which are used for different purposes. Most commonly it comes down to two types, either preparation replicates or measurement replicates. In the case of preparation, these are samples or standards that are prepared from the beginning to end of the procedure in the same way but separately (often referred to as replicate weighings). In the case of measurement replicates, a single sample/standard is measured more than once (an example would be multiple injections in the case of HPLC). Standard Preparation Replicates in calibration standard preparation are often used to provide confidence in the initial weighing of the standard material. The idea is that if the response is corrected using the actual amount which was weighed out, then the response factors will be the same if the weighing has been performed correctly. This may apply in the case of single point calibrations, where a single concentration of standard is used for the calibration, or in multi-level calibration where the original weighing is diluted to prepare a series of standards over a range of concentrations. The difficult part is setting an acceptance criteria for the required agreement between these replicate standards. Duplicate preparation is common since it requires the least amount of extra work but two results cannot be compared using common statistical tools, such standard deviation. Usually the agreement is expressed as a percentage of one result compared to the other. How close this should be to 100% will depend on the inherent error in the method and the considerations are similar to those in setting acceptance criteria during method validation. ... https://www.linkedin.com/pulse/replicates-analytical-methods-when-how-many-oona-mcpolin |
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