Prior to the randomized part of the study, a safety run-in phase involving 18 patients was completed as planned at 500, 1,000, and 2,000 mg dose levels.
http://www.allbusiness.com/medicine-health/diseases-disorder...

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Note added at 22 mins (2010-02-12 21:43:45 GMT)
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просто: с определением безопасных доз

There will be a short safety run in portion of the study to determine the optimal treatment regimen (OTR) for the combination, since these two drugs have not previously been used together.
http://www.gsk-clinicalstudyregister.com/protocol_detail.jsp...

Safety Run-In: Will determine the maximum tolerated dose of the study drug in subjects with metastatic pancreatic adenocarcinoma.
http://clinicaltrials.nlm.nih.gov/ct2/show/NCT01016483