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English to German: MRes Thesis Abstract C Lange General field: Science Detailed field: Chemistry; Chem Sci/Eng
Source text - English Tubulysins, first isolated from myxobacteria in 2004, are a family of tubulin polymerisation inhibitors that destabilise microtubules, thereby inducing cell death. Their ability to suppress the growth of cancer cells exceeds that of existing tubulin targeting cancer drugs, (vinblastine and taxol) by a factor of between 20 and 100. This makes them important synthetic targets in the development of new anti-cancer leads, and much effort over the last 5 years has focussed on developing pharmacologically optimised derivatives with only the most essential structural features.
Natural tubulysins consist of four amino acid fragments: Mep, L-Ile and two unusual amino acids tubuvaline (Tuv) and either tubutyrosine (Tut for tubulysins A, B, C, G and I) or tubuphenylalanine (Tup, tubulysins D, E, F and H), fused through a central thiazole ring.
The present approach uses a very simple route towards the assembly of a modified version of the challenging Tuv-Tup segment of this molecule. In this mimetic, the central thiazole ring and adjacent amino acid sub-unit are replaced with a triazole ring, whilst maintaining the stereochemical orientation of the natural parent molecule and simplifying the skeleton to the minimum functional group requirements identified in earlier work.
The synthesis of the two-amino-acid sub-unit was accomplished in a convergent synthesis of nine overall steps, starting from simple amino acid building blocks and using readily available and cheap reagents.
This new approach paves the way for the synthesis of new tubulysin mimetics incorporating the central triazole motif in as few as nine steps.
Translation - German Bei Tubulysinen, welche erstmalig in 2004 von Myxobakterien isoliert wurden, handelt es sich um eine Familie von Tubulin-Polymerisationshemmern, die Mikrotubuli destabilisieren und damit den Zelltod auslösen. Ihre wachstumshemmende Wirkung bei Krebszellen übersteigt die der bestehenden, Tubulin angreifenden Pharmaka (Vinblastin und Taxol) um einen Faktor von 20 bis 100. Damit sind Tubulysine bedeutende Syntheseziele in der Entwicklung von neuen Krebsmittelvorläufern, und viel Forschungsaufwand in den letzten 5 Jahren war auf die Entwicklung von pharmakologisch optimierten Derivaten unter Beibehaltung der wichtigsten Strukturmerkmale ausgerichtet.
In der Natur vorkömmliche Tubulysine bestehen aus vier Aminosäurefragmenten : MEP , L-Ile und zwei weniger gewöhnlichen Aminosäuren Tubuvalin ( Tuv ) und entweder Tubutyrosin ( Tut Tubulysin für A, B, C, G und I) oder Tubuphenylalanine ( Tup , Tubulysin D, E, F und H), kondensiert über einen zentralen Thiazolring.
Mit dem vorliegenden Ansatz wird ein sehr einfacher Weg in Richtung der Synthese einer modifizierten Version des anspruchsvollen Tuv-Tup Abschnittes dieses Moleküls eingeschlagen. In diesem Mimetikum wurden der zentrale Thiazolring und die angrenzende Aminosäureuntereinheit mit einem Triazolring ersetzt, mit Erhalt der stereochemischen Orientierung des natürlichen Ausgangsmoleküls und Simplifizierung des Skeletts auf die mindestens erforderlichen Funktionsgruppen, welche in früheren Arbeiten identifiziert wurden.
Die Synthese der zwei Aminosäureuntereinheiten wurde in einer konvergenten Synthese mit insgesamt neun Schritten erreicht, ausgehend von simplen Aminosäure-Bausteinen und unter Einsatz von leicht erhältlichen und preisgünstigen Reagenzien.
Dieser neue Ansatz ebnet den Weg für die Synthese weiterer Tubulysin-Mimetika unter Einbeziehung des zentralen Triazol-Motivs in nur neun Stufen.
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Years of experience: 34. Registered at ProZ.com: Dec 2013.
Born and educated in Germany, I have more than 20 years of translation and editing experience and specialize in pharmaceutical and medical device SOPs and in medical reports, more recently focusing on the new growth area of genetic engineering. In my early training I benefited from more than 4 years working as a medical secretary in Germany - deciphering handwritten doctors' notes is my speciality!
My degree education was conducted entirely in English, and I gained a Masters by Research in Organic Chemistry at Nottingham following part time study with the Open University for my undergraduate degree.
In addition to this I can offer many years of employment history in Sales and Marketing for medical device, pharmaceutical and industrial automation companies, so I have hands-on experience of the industries that I specialize in. In the course of this, I have acquired a lot of technical vernacular language that leaves many conventionally trained translators stranded.
Keywords: German, English, translation, transcription, subtitling, organic synthesis, chemistry, medical devices, biotechnology, polymer. See more.German, English, translation, transcription, subtitling, organic synthesis, chemistry, medical devices, biotechnology, polymer, technology, adhesives, automation, genetics, epidemiology, virology. See less.
