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English to German: Abstract of a review General field: Science Detailed field: Medical: Pharmaceuticals
Source text - English Cytochrome P450 enzymes (CYPs or P450s) are the most important enzymes involved in the phase I metabolism of drugs and poisons in humans, while UDP glycosyltransferases catalyze the majority of phase II reactions. In addition, a number of other enzymes or enzyme families contribute to the metabolism of xenobiotica, including alcohol dehydrogenase, aldehyde dehydrogenase, ester and amide hydrolases, epoxide hydrolase and flavine monooxygenases, as well as sulfotransferases, catechol-O-methyltransferase and N-acetyltransferase. A thorough understanding of their activity and of the properties of the metabolites they form is an essential prerequisite for the assessment of drug-caused side effects or toxicity. In this context of MIST, efficient production systems are needed to permit the large-scale production of human drug metabolites. As classical chemical synthesis cannot always provide these metabolites, biotechnological approaches have been developed that typically employ the recombinant expression of human drug-metabolizing enzymes. This review summarizes the current knowledge regarding whole-cell biotransformation processes that make use of such an approach.
Translation - German Cytochrom P450-Enzyme (CYPs oder P450s) sind die wichtigsten der am Phase I-Metabolismus von Wirkstoffen und Giften beteiligten Enzyme, während UDP-Glucuronosyltransferasen die Mehrzahl der Phase II-Reaktionen katalysieren. Darüber hinaus sind noch eine Reihe anderer Enzymfamilien am Fremdstoff-Metabolismus beteiligt, zum Beispiel Alkohol-Dehydrogenase, Aldehyd-Dehydrogenase, Ester- und Amid-Hydrolasen, Epoxid-Hydrolase und Flavin-Monooxigenasen, sowie Sulfotransferasen, Katechol-O-Methyltransferase und N-Acetyltransferase. Ein tiefgehendes Verständnis ihrer Aktivität sowie der Eigenschaften der von ihnen gebildeten Metabolite ist eine notwendige Voraussetzung für die Bewertung von Nebenwirkungen oder Toxizität, die vom Wirkstoff verursacht werden. In diesem MIST-Zusammenhang sind effiziente Produktionssysteme notwendig zur Produktion humaner Wirkstoff-Metabolite in großem Maßstab. Da die klassische chemische Synthese diese Metabolite nicht immer darstellen kann wurden biotechnologische Ansätze entwickelt, die typischerweise auf der rekombinanten Expression humaner Fremdstoff-metabolisierender Enzyme beruhen. Dieser Übersichtsartikel faßt das gegenwärtige Wissen bezüglich der Ganzzell-Biotransformationen, die sich eines solchen Ansatzes bedienen, zusammen.
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Experience
Years of experience: 30. Registered at ProZ.com: Jul 2012.
Microsoft Excel, Microsoft Office Pro, Microsoft Word, Powerpoint, Trados Studio
Bio
I am a Biotechnology entrepreneur and have been in science since 1992. So why do I also do translation? It’s true that it pays much less, but it’s just as rewarding and offers a working pattern that is more compatible with family life (and, who knows, living abroad). Moreover, I am married to a professional translator (German native, university diploma for translation; English and French), so that's an additional incentive in this direction.
As a scientist I am immersed in science language every working day, and regularly write monolingual (English) publications. I am uniquely placed to produce translations with an authentic scientific style, while remaining faithful to the source text. I am helped by my large experience of scientific writing, as I have 37 original research publications (including 16 as senior author), three reviews, three book chapters and eight patent applications to my name. Needless to say I bring the same professionalism to my translation work that is required of me in my scientific work.
My other working fields reflect my areas of interest and expertise – I don’t take on translation work in areas I am not familiar with.
Keywords: English to German, life science, biotechnology, pharmacology, medicine, genetics, molecular biology, drug metabolism, recombinant protein expression, cancer research