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Specializes in:
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Sample translations submitted: 4
English to Chinese: Medical
Source text - English Gene Mutations in Apical Hypertrophic Cardiomyopathy
From the Department of Genetics, Harvard Medical School, Boston, Mass (M.A., S.B., M.K., J.G.S., C.E.S.); Heart Institute, Sheba Medical Center, Tel Hashomer, Israel (M.A.); Cardiology Service, Hospital Juan Canalejo, La Coruña, Spain (M.P.-L., L.M.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (B.J.M.); St Luke’s Roosevelt University Hospital, New York, NY (M.S.); Division of Cardiology and Howard Hughes Medical Institute, Brigham and Women’s Hospital, Boston, Mass (C.Y.H., C.E.S.); Division of Cardiology, Wright State University, Dayton, Ohio (A.K.); Mayo Clinic Cardiovascular Genetics Laboratory, Rochester, Minn (T.M.O.); and Department of Pediatrics, Nippon Medical School, Tokyo, Japan (M.K.).
Background— Non-obstructive hypertrophy localized to the cardiac apex is an uncommon morphological variant of hypertrophic cardiomyopathy (HCM) that often is further distinguished by distinct giant negative T waves and a benign clinical course. The genetic relationship between HCM with typical hypertrophic morphology versus isolated apical hypertrophy is incompletely understood.
Methods and Results— Genetic cause was investigated in 15 probands with apical hypertrophy by DNA sequence analyses of 9 sarcomere protein genes and 3 other genes (GLA, PRKAG2, and LAMP2) implicated in idiopathic cardiac hypertrophy. Six sarcomere gene mutations were found in 7 samples; no samples contained mutations in GLA, PRKAG2, or LAMP2. Clinical evaluations demonstrated familial apical HCM in 4 probands, and in 3 probands disease-causing mutations were identified. Two families shared a cardiac actin Glu101Lys missense mutation; all members of both families with clinical manifestations of HCM (n=16) had apical hypertrophy. An essential light chain missense mutation Met149Val caused apical or midventricular segment HCM in another proband and 5 family members, but 6 other affected relatives had typical HCM morphologies. No other sarcomere gene mutations identified in the remaining probands caused apical HCM in other family members.
Conclusions— Sarcomere protein gene mutations that cause apical hypertrophy rather than more common HCM morphologies reflect interactions among genetic etiology, background modifier genes, and/or hemodynamic factors. Only a limited number of sarcomere gene defects (eg, cardiac actin Glu101Lys) consistently produce apical HCM.
Translation - English Road engineering refers to all types of road construction, including the bridges, tunnels, retaining walls and viaducts along the route of the road. But the construction cost of the bridges, tunnels, retaining walls and iaducts shall not exceed20% of the total cost of construction of the agreed
contract. Otherwise, individual applicable loss chart shall be applied to hese items.
When using the benchmark statistics' initial amount as the deductible, its loss rate shall be set according to the loss rate table. When using a larger amount as the deductible, the adjustment factor in loss rate chart shall be used accordingly in computing the adjustments. When the net loss rate table does not provide specific adjustment factor, the actuary shall give a reasonable estimate based on the chart's data. For example, when using double (2x) the benchmark statistics' initial amount, the loss rate factor is 0.925, and for five times the initial amount, the factor is 0.85. The factors for triple (3x), quadruple (4x) or any other amount are not provided in the table, at this time straight line fitting methed can be use to determine that loss rate factor for 3 times the initial amount is 0.95, the factor for 4 times is 0.875, so on and so forth.
English to Chinese: drug literature General field: Medical Detailed field: Medical: Pharmaceuticals
Source text - English XXX
15 mg/ 25 mg/ 325 mg Capsule
10 mg/ 12.5 mg/ 250 mg per 5 ml Suspension
REFORMULATED
Patient Package Insert and Prescribing Information
INDICATIONS: For the relief of cough, nasal congestion, headache and fever associated with the common cold.
GENERAL PRECAUTIONS: Do not take this product if you have heart disease, hypertension, thyroid disease, glaucoma, and difficulty in urination due to the enlargement of the prostate – unless directed by a doctor. Do not take this product for persistent or chronic cough which occurs with smoking, emphysema or if cough is associated with excessive phlegm.
Consult a doctor if:
• The cough persists for more than 1 week or if it gets worse
• The cough is accompanied by a recurring fever
• You have any new or unusual symptoms
• You have breathing problems such as asthma, emphysema and chronic bronchitis
• You are pregnant or nursing a baby
Keep this and all other drugs out of the reach of children.
ACTIVE INGREDIENTS: Each capsule contains 15 mg of Dextromethorphan Hydrobromide, 25 mg of Phenylpropanolamine Hydrochloride, and 325 mg of Paracetamol.
Each 5ml suspension contains 10 mg of Dextromethorphan Hydrobromide, 12.5 mg of Phenylpropanolamine Hydrochloride, and 250 mg of Paracetamol.
DIRECTIONS: To be taken every 6 hours, the dose for adults is one capsule or 10 ml (2 teaspoonfuls) of the suspension. Children from 7 to 12 years can take5 ml or one teaspoonful of suspension; and children from 2 to 6 years, 2.5 ml or ½ teaspoon.
DEXTROMETHORPHAN Hydrobromide is a methylated dextro-isomer of levorphanol but unlike its levorotatory congener, it has no significant properties and does not depress respiration or predispose to addiction. It diminishes the cough reflex through its depressant action on the cough center in the medulla at a degree equal to codeine.
PHENYLPROPANOLAMINE Hydrochloride is a synthetic phenylisopropanolamine sympathomimetic agent. It presumably acts on alpha-adrenergic receptors in the respiratory tract producing vasoconstriction resulting in reduction of tissue hyperemia and edema.
PARACETAMOL produces analgesia and antipyresis by a mechanism similar to that of salicylates. It acts on the hypothalamus to produce antipyresis; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow. Paracetamol lowers body temperature when fever is present but rarely lowers body temperature in normal patients.
CONTRAINDICATIONS/WARNINGS/PRECAUTIONS: Contraindicated in patients receiving monoamine oxidase (MAO) inhibitors.
Paracetamol should be discontinued if hypersensitivity reaction occurs. It should be used with caution in patients with pre-existing anemia, since cyanosis may no be apparent despitedangerously high blood concentrations of methemoglobin. Repeated administration is contraindicated in patients with anemia and cardiac, pulmonary, renal or hepatic disease.
WARNING
• Use with caution in patients with high blood pressure, toxic goiter, benign prostatic hypertrophy, heart rate irregularity, glaucoma, and in those taking antidepressants.
• Patients with heart disease and uncontrolled/untreated high blood pressure shouldconsult a physician prior to taking PPA.
CAUTION: Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.
AVAILABILITY: Capsule – Box of 100’s
Suspension – Bottles of 60 and 120 ml
For Capsule:
STORE AT TEMPERATURES NOT EXCEEDING 30ºC
For Suspension:
STORE AT TEMPERATURE NOT EXCEEDING 30ºC
SHAKE WELL BEFORE USING.
Translation - English An excellent medicine that is essential wherever you are.
A powder mix for treatment of common cold, productive cough and nasal congestion.
“Common cold is the root of all diseases。” Common cold is the most common disease that occurs all year round. Even though its condition is not serious but it may lead to complications such as bronchitis, pneumonia，encephalitis and myocarditis. We should never take it for granted!
“Weak energy predisposes to pathogenic invasion.” Common cold is mostly due to variable weather brought about by changing seasons, extreme fatigue（insufficient rest）and poor diet（eating raw and yin foods that can damage the spleen）. It causes the body to accumulate heat, vital energy deficiency, weak lung energy, unstable defense energy and external pathogenic wind invading the lungs.
“Vital energy defends the body from pathogenic factors.” This product was made from pure traditional Chinese herbs and prepared according to the great physician Sun Simiao’s theories about ‘strengthening vital energy to dispel pathogenic factors’ and ‘common cold prevention’ with the use of modern scientific technique in extracting its essence. The various traditional Chinese herbs act synergistically in strengthening vital energy, stabilizing defense energy, strengthening the body resistance and thereby rapidly dispelling the external pathogenic factors. This prescription is effective in strengthening vital energy. It cures both symptoms and causes of the disease. It was able to achieve ideal results and became an excellent medicine that is essential to carry with you wherever you are.
Main ingredients：（Each sachet contains active ingredients equivalent to that of the raw herbs）
Tangerine peel (Pericarpium Citri Reticulatae) 5000 mg, Pinellia Tuber (Rhizoma Pinelliae) 1500 mg,
Purple Perilla Leaf (Folium Perillae) 1500 mg, Hogfennel Root (Radix Peucedani) 1000 mg,
Almond (Semen Armeniacae Amarum) 1000 mg, Ballonflower root (Radix Platycodi) 1000 mg,
Indian bread (Poria cocos) 1000 mg, Liquorice Root (Radix Glycyrrhizae) 500 mg。
This product was made purely from traditional Chinese herbs, preparation of this product was in accordance to the Traditional Chinese Patent Medicine Standard set by the Ministry of Health of People’s Republic of China.
Drug effects: Dispel wind and cold, dissolve phlegm and stop the cough. (Stop nasal drip
