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Spanish to English: Summary General field: Science Detailed field: Biology (-tech,-chem,micro-)
Source text - Spanish RESUMEN
Las artropatías microcristalinas son patologías inflamatorias inducidas por reacción celular al depósito de cristales en las articulaciones, resultan de la combinación de factores sistémicos y locales.
Las miopatías se caracterizan por el estado anormal del músculo esquelético caracterizado por debilidad, consunción y cambios histológicos; se deben a múltiples causas y ocasionan problemas en el tono y la contracción con diferentes grados de severidad, entre ellas las “miopatías inflamatorias” originadas tanto por factores endógenos como exógenos.
En búsqueda de una terapia antiinflamatoria libre de los efectos adversos que provocan los antiinflamatorios no esteroideos (AINEs), se propone el tratamiento con láser de baja potencia, como el de Helio-Neón (He-Ne).
Se estudió el efecto antiinflamatorio del láser de He-Ne en modelos experimentales de artropatías inducidas por cristales de hidroxiapatita (HP) y de pirofosfato cálcico (PFCa) en ratas, en diferentes períodos de tiempo, determinando marcadores plasmáticos inflamatorios y de estrés oxidativo: fibrinógeno, L-citrulina, óxido nítrico (ON) y nitrotirosina, estudio histomorfológico y comparación con AINEs.
Se utilizó 120 ratas hembras, distribuidas en 15 grupos. La artropatía se indujo por inyección intraarticular de 2mg de HP o PFCa en miembros posteriores. En un grupo se inyectó cristales durante 3 días seguidos y en otro durante 2 semanas (día por medio). Tratamiento con láser de He-Ne se realizó por 3 días consecutivos sobre las articulaciones afectadas en el 1º grupo y por 5 días en el 2º grupo. El tratamiento con AINEs: 1,25mg/día/rata de diclofenac y meloxicam; y 0.05mg/día/rata de celecoxib y rofecoxib, individualmente en 3 oportunidades cada 24 hs. después de inyectar HP. La histología se realizó por microscopía óptica. La determinación de marcadores se realizó por espectrofotometría; y se utilizó ANOVA - test de Fisher (p
Translation - English SUMMARY
Microcrystalline arthropaties are inflammatory pathologies induced by a cellular reaction to the deposit of crystals in the joints; they result from the combination of systemic and local factors. Myophaties are characterized by the abnormal condition of the skeletal muscles characterized by weakness, consumption and histological changes; these have multiple causes and they bring about problems in the muscular tone and contraction with different degrees of severity, such as the "inflammatory myophaties" triggered not only by endogenous but also exogenous factors.
In the search of an anti-inflammatory therapy free of the adverse effects caused by the NSAID (non-steroidal anti-inflammatory drug), it is proposed a treatment with a low-power laser, such as the Helium- Neon (He-Ne).
The anti-inflammatory effect of the He-Ne laser was studied in experimental models of artrophaties induced by Hydroxyapatite crystals and calcium pyrophosphate in laboratory rats, in different periods of time, determining plasma inflammatory markers and of oxidative stress: fibrinogen, L-citrulline, nitric oxide (NO) and nitrotyrosine, histomorphologic study and comparison with NSAIDs.
120 female rats were used, distributed in 15 groups. The artrophaty was induced by intraarticular injection of 2mg of Hydroxyapatite crystals or calcium pyrophosphate in the back limbs. In one group crystals were injected during a period of three consecutive days and in another group during two weeks (every other day). The He-Ne laser treatment was carried out for 3 consecutive days on the affected joints in the first group and for 5 days in the second group. The treatment with NSAIDs : 1.25mg/day/rat of diclofenac and meloxicam; and 0.05mg/day/rat of celecoxib and rofecoxib individually in three occasions every 24 hours after injecting Hydroxyapatite. The histology was performed with optical microscopy. The determination of markers was done with spectrophotometry; and ANOVA -Fisher test ( p
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Years of experience: 18. Registered at ProZ.com: Oct 2005.
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Translator of English graduated from the School of Languages, University of
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and excellence in the field of linguistics.
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