преобразуются/по всей длине
| 17:25 Sep 23, 2019 |
| Russian to English translations [PRO] Science - Biology (-tech,-chem,micro-) / молекулы нуклеиновых кислот преобразуются в гены антитела | |||||||
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| 3 | converted along the entire length |
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| Discussion entries: 3 | |
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Answers
6 mins confidence: 
converted along the entire length Explanation: In another aspect of the present invention, nucleic acid molecules encoding the variable domain of a heavy (VH) and / or light (VL) chains of the first or second binding domain can be "transformed" along the entire length of the antibody genes. In one embodiment of the invention, nucleic acid molecules encoding the VH or VL domains are converted into antibody genes along the entire length by insertion into an expression vector that already encodes the constant domains of the heavy chain (CH) or light chain (CL), respectively, so that the VH segment is functionally connected to the CH segment (s) in the vector and / or the VL segment is operatively connected to the CL segment in the vector. In another embodiment of the invention, nucleic acid molecules encoding the VH and / or VL domains are converted into genes along the entire length of the antibody by connecting, for example, ligation, a nucleic acid molecule encoding the VH and / or VL domains to a nucleic acid molecule encoding CH and / or CL domains using standard molecular biological methods. Nucleic acid molecules that encode the heavy and / or light chain throughout their length can then be expressed in the cell into which they were inserted. Nucleic acid molecules can be used to express large amounts of recombinant antibodies to CD47 and PD-L1. Nucleic acid molecules can be used to produce human antibodies, humanized antibodies, chimeric antibodies, bispecific antibodies, single-chain antibodies, immunoadhesins, diabodies, mutated antibodies, and derivatives of antibodies, as described herein. https://patents.google.com/patent/WO2019068302A1/en -------------------------------------------------- Note added at 11 mins (2019-09-23 17:36:58 GMT) -------------------------------------------------- This English text also uses "transformed" in quotation marks, corresponding to the use of «преобразовываться» in the Russian text. https://patents.google.com/patent/WO2019068302A1/ru |
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