motif de clivage (de l'hémagglutinine)

English translation: cleavage motif

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase:motif de clivage (de l'hémagglutinine)
English translation:cleavage motif
Entered by: Dana Pottratz

14:49 Mar 16, 2009
French to English translations [PRO]
Science - Biology (-tech,-chem,micro-) / Virology
French term or phrase: motif de clivage (de l'hémagglutinine)
Here's the (very long!) context:

"Les laboratoires agréés réalisent les tests de RT-PCR temps réel de première intention consistant 1- à détecter la présence de virus influenza quel que soit le sous type impliqué et 2- en cas de positivité à détecter la présence ou non de virus de sous type d'hémagglutinine H5. En cas de positivité, le LNR prend le relais :
- soit, si un virus H5 a été détecté, pour immédiatement confirmer ou exclure la présence de virus H5N1 hautement pathogènes du clade 2.2 (présent en Europe en 2006-2008) et dans tous les cas pour confirmer ou déterminer les caractéristiques de virulence du virus H5 par séquençage du **motif de clivage de l'hémagglutinine** ;
- soit, en l'absence de mise en évidence de virus H5, pour, sans délai, exclure ou non la présence de virus de sous types d'hémagglutinine H7 et en cas de positivité déterminer les caractéristiques de virulence du virus H7 par séquençage du **motif de clivage de l'hémagglutinine**.

Thanks in advance,

Dana
Dana Pottratz
France
Local time: 18:03
cleavage motif
Explanation:
I see no reason not to use motif like the French.

http://jmd.amjpathol.org/cgi/content/abstract/10/3/225
"Direct Sequence Detection of Structured H5 Influenza Viral RNA
[...]
The abundance frequencies of the hemagglutinin cleavage motif and sialic acid recognition sequences were experimentally tested for H5 in all host viral species"

http://www.ncbi.nlm.nih.gov/pubmed/8790895
"All repository HP H5 and H7 viruses studied had multiple basic amino acids adjacent to the HA cleavage site and most had basic amino acids in excess of the proposed minimum motif B-X-B-R (B = basic amino acids arginine or lysine, X = nonbasic amino acid, R = arginine) that has been associated with high pathogenicity. Of the non-HP viruses studied, 35 of 38 for H5 and 30 of 31 for H7 conformed to the motif B-X-X-R and B-X-R, respectively. Two non-HP H5 viruses had the motif X-X-X-R at the cleavage site and a third had the motif B-X-X-K (K = basic amino acid lysine). "
Selected response from:

Helen Genevier
France
Local time: 18:03
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +3cleavage motif
Helen Genevier
5 +1cleavage site
:::::::::: (X)
5cleavage site
Lionel_M (X)
4hemagglutinin cleavage sequence (pattern)
Drmanu49
3(hemagglutinin) cleavage site motif
CFournier


  

Answers


6 mins   confidence: Answerer confidence 5/5 peer agreement (net): +1
cleavage site


Explanation:
cleavage site

:::::::::: (X)
Iraq
Local time: 18:03
Native speaker of: Native in EnglishEnglish
PRO pts in category: 20
Notes to answerer
Asker: what about cleavage pattern? I don't see how "motif" can be translated as "site" - or maybe I'm missing something?


Peer comments on this answer (and responses from the answerer)
agree  Hervé du Verle
1 min
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8 mins   confidence: Answerer confidence 5/5
cleavage site


Explanation:
Sorry Dana; know it's in English as shown in references bellow

[PDF] PROCEEDINGS OF THE JOINT ELEVENTH ANNUAL MEETINGS OF THE NATIONAL ... - [ Traduire cette page ]Format de fichier: PDF/Adobe Acrobat
cleavage site of the hemagglutinin that is compatible with other HPAI viruses ...... clivage site F gene = GKQGRL. H5 AIV genetic characteristics ...
ec.europa.eu/food/animal/diseases/controlmeasures/proceedings2005.pdf - Pages similaires
de H AT - Autres articles
I C- S N P : Comparison of polymerase-nucleocapsid interaction ...cleavage site (CTGGTGCCGCGCGGCAGC) was replaced by a TEV clivage site ...... Isolation of new virus possessing hemagglutinin activity. Yokohama Med. Bull. ...
jvi.asm.org/cgi/reprint/JVI.00338-07v1.pdf - Pages similaires
de K Houben - 2007 - Cité 4 fois - Autres articles - Les 6 versions

--------------------------------------------------
Note added at 14 mins (2009-03-16 15:03:12 GMT)
--------------------------------------------------

please read "now it's in English..." Sorry !

Lionel_M (X)
Local time: 18:03
Specializes in field
Native speaker of: Native in FrenchFrench
PRO pts in category: 55
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23 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
hemagglutinin cleavage sequence (pattern)


Explanation:
(a) Cell pellets; (b) cleavage patterns of released A/Aichi/2/68 virus. ..... Role of hemagglutinin cleavage for the pathogenicity of influenza virus. ...
jvi.asm.org/cgi/content/full/76/17/8682?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext...1...

(HP), ratite-origin, H5N2 avian influenza derivative shares the same hemagglutinin cleavage sequence as recent HP Mexican H5N2 isolates. In: 14th Annual ...
www.jstor.org/stable/1592242

Drmanu49
France
Local time: 18:03
Works in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 91
Login to enter a peer comment (or grade)

26 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
cleavage motif


Explanation:
I see no reason not to use motif like the French.

http://jmd.amjpathol.org/cgi/content/abstract/10/3/225
"Direct Sequence Detection of Structured H5 Influenza Viral RNA
[...]
The abundance frequencies of the hemagglutinin cleavage motif and sialic acid recognition sequences were experimentally tested for H5 in all host viral species"

http://www.ncbi.nlm.nih.gov/pubmed/8790895
"All repository HP H5 and H7 viruses studied had multiple basic amino acids adjacent to the HA cleavage site and most had basic amino acids in excess of the proposed minimum motif B-X-B-R (B = basic amino acids arginine or lysine, X = nonbasic amino acid, R = arginine) that has been associated with high pathogenicity. Of the non-HP viruses studied, 35 of 38 for H5 and 30 of 31 for H7 conformed to the motif B-X-X-R and B-X-R, respectively. Two non-HP H5 viruses had the motif X-X-X-R at the cleavage site and a third had the motif B-X-X-K (K = basic amino acid lysine). "

Helen Genevier
France
Local time: 18:03
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 56

Peer comments on this answer (and responses from the answerer)
agree  Lionel_M (X): this is perfect Helen; you're right (again)
9 mins

agree  Jean-Louis S.
32 mins

agree  SJLD
1 hr
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27 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
(hemagglutinin) cleavage site motif


Explanation:
Normalement un site de clivage EST déjà un motif de clivage.

Mais si vous voulez vraiment très très très précise, je vous propose ce lien qui donne "cleavage site motif", dans un brevet rédigé originellement en anglais.

http://www.wipo.int/pctdb/fr/wo.jsp?WO=2002038796

Là aussi : http://cat.inist.fr/?aModele=afficheN&cpsidt=19752627


    Reference: http://www.wipo.int/pctdb/fr/wo.jsp?WO=2002038796
    Reference: http://cat.inist.fr/?aModele=afficheN&cpsidt=19752627
CFournier
France
Local time: 18:03
Specializes in field
Native speaker of: Native in FrenchFrench
PRO pts in category: 4
Login to enter a peer comment (or grade)



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