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doser par Biacore par le jeu de 2 anticorps de spécificité differente

English translation: Biacore based assay using a set of two antibodies with different specificity

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase: doser par Biacore par le jeu de 2 anticorps de spécificité differente English translation: Biacore based assay using a set of two antibodies with different specificity Entered by: Lionel_M (X)

17:17 Feb 16, 2009

French to English translations [PRO] Science - Biology (-tech,-chem,micro-)
French term or phrase: doser par Biacore par le jeu de 2 anticorps de spécificité differente doser par Biacore par le jeu de 2 anticorps de spécificité differente greffés sur des canaux différents This is a Biacore assay for selecting monoclonal antibodies that bind to the antigen. I'm having problems with "le jeu de". Would this be 2 antibodies with different affinities ie. competing antibodies?	angly KudoZ activity Questions: 172 (2 open) Answers: 1 Local time: 11:04
Biacore based assay using a set of two antibodies with different specificity Explanation: suggestion	Selected response from: Lionel_M (X) Local time: 11:04
Grading comment thanks 4 KudoZ points were awarded for this answer

Summary of answers provided
4 +3	Biacore based assay using a set of two antibodies with different specificity	Lionel_M (X)

Discussion entries: 6

Lionel_M (X) 15:16 Feb 17, 2009  Your absolutely right again ! I agree since I also use Biacore; we never know about steric effects in particular for small (or globular) targeted proteins. Dr Lofthouse France 15:03 Feb 17, 2009  I make it 'assayed by Biacore using 2 specific antibodies to different epitopes .' too. Technically speaking, it doesnt mean they dont 'compete' though, as they could have steric effects (I'm being a scientific purist here angly - sorry, its m'day job!) Lionel_M (X) 09:34 Feb 17, 2009  exactly ! angly ASKER 09:21 Feb 17, 2009  Hi, as far as I can tell it is 2 antibodies binding to different epitopes on the same protein. Does that make sense? Lionel_M (X) 00:24 Feb 17, 2009  Correct ! Indeed Ab libraries are also screened w/Biacore. Not only "complete" Ab but Fab'2 too. http://www.wipo.int/pctdb/en/wo.jsp?WO=2007109567&IA=US20070... Dr Lofthouse France 20:54 Feb 16, 2009  You should be able to tell from the binding plot (if there is one) - I find the text ambiguous in translation because - '2 antibodies with different specificities' can bind to the same protein, but at different sites. Automatic update in 00:

  

Answers

34 mins   confidence: peer agreement (net): +3

Biacore based assay using a set of two antibodies with different specificity Explanation: suggestion	Lionel_M (X) Local time: 11:04 Specializes in field Native speaker of: French PRO pts in category: 55
Grading comment thanks
Peer comments on this answer (and responses from the answerer) agree  Drmanu49: www.biacore.com/jp/food/press/pressreleases/4281/index.html - 33k - 56 mins   -> Merci Doc neutral  Dr Lofthouse: Does this press release refer to the same MoAbs referred to in the text though?? 3 hrs   -> How should we know w/o details about this Kudows ? But why do you ask me ? Anyway, the "Biacore" works always the same way. agree  raptisi 19 hrs   -> Thank You agree  CFournier 1 day 3 hrs   -> Merci C.
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