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localization

English translation: (in this context) the part of the kidney filtering unit which is responsible for the proteinuria.

00:19 Nov 22, 2006
English language (monolingual) [PRO]
Medical - Medical: Instruments
English term or phrase: localization
Complete UA is an important tool for the diagnosis and localization of protein-losing glomerulopathies and for differentiating this from other causes of decreased serum albumin concentration.

What does "localization" mean here?

Thank you in advance!
Jianming Sun
Local time: 00:57
Selected answer:(in this context) the part of the kidney filtering unit which is responsible for the proteinuria.
Explanation:
The filtering apparatus of the kidney is a complex structure that can "go wrong" in several different places. "Localization" refers to determining the PARTof the structure which is diseased or otherwise responsible for the protein loss.

See this exerpt from Uptodate:
The presence of some form of glomerular disease, as opposed to primary tubulointerstitial or vascular disease, is usually suspected from the history and from one or more of the following urinary findings: hematuria (particularly if the red cells have a dysmorphic appearance), red cell casts, lipiduria (since glomerular permeability must be increased to allow the filtration of large lipoproteins), and proteinuria, which may be in the nephrotic range (greater than 3 g/day). (See "Hematuria: Glomerular versus extraglomerular bleeding", see "Significance of lipiduria" and see "Evaluation of isolated proteinuria in adults" and see "Evaluation of proteinuria in children").

Despite these clues, the ability to distinguish renal disease due to some form of glomerular disorder from that due to chronic tubulointerstitial involvement may be difficult. Although tubulointerstitial disease does not directly increase protein excretion, nephron loss can induce secondary glomerulosclerosis leading to proteinuria that may reach the nephrotic range. Such patients may be erroneously considered to have a primary glomerular disease. This topic will review those clinical features most consistent with the various forms of glomerular disease.

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Note added at 1 hr (2006-11-22 01:50:04 GMT)
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That should be excerpt, not exerpt.
Selected response from:

Michael Barnett
Local time: 12:57
Grading comment
Thank you both for kind help!
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
4 +5(in this context) the part of the kidney filtering unit which is responsible for the proteinuria.
Michael Barnett
4 +2Please see link below. Noun, number 2
Anna Maria Augustine (X)


  

Answers


13 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
Please see link below. Noun, number 2


Explanation:
It is explained here:

http://www.thefreedictionary.com/Localization

Anna Maria Augustine (X)
France
Local time: 18:57
Works in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 8
Notes to answerer
Asker: Thanks! But I do know the general meaning of the word. What I meant was its true meaning in the medical context in the paragraph.


Peer comments on this answer (and responses from the answerer)
agree  Alexander Demyanov: I believe in the particular context it's number 3, not 2. This is about diagnostics rather than treatment.
49 mins
agree  Dave Calderhead: In the Medical dictionary, no. 3 = 3. The determination of the location of a pathological process
1 hr
Login to enter a peer comment (or grade)

1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +5
(in this context) the part of the kidney filtering unit which is responsible for the proteinuria.


Explanation:
The filtering apparatus of the kidney is a complex structure that can "go wrong" in several different places. "Localization" refers to determining the PARTof the structure which is diseased or otherwise responsible for the protein loss.

See this exerpt from Uptodate:
The presence of some form of glomerular disease, as opposed to primary tubulointerstitial or vascular disease, is usually suspected from the history and from one or more of the following urinary findings: hematuria (particularly if the red cells have a dysmorphic appearance), red cell casts, lipiduria (since glomerular permeability must be increased to allow the filtration of large lipoproteins), and proteinuria, which may be in the nephrotic range (greater than 3 g/day). (See "Hematuria: Glomerular versus extraglomerular bleeding", see "Significance of lipiduria" and see "Evaluation of isolated proteinuria in adults" and see "Evaluation of proteinuria in children").

Despite these clues, the ability to distinguish renal disease due to some form of glomerular disorder from that due to chronic tubulointerstitial involvement may be difficult. Although tubulointerstitial disease does not directly increase protein excretion, nephron loss can induce secondary glomerulosclerosis leading to proteinuria that may reach the nephrotic range. Such patients may be erroneously considered to have a primary glomerular disease. This topic will review those clinical features most consistent with the various forms of glomerular disease.

--------------------------------------------------
Note added at 1 hr (2006-11-22 01:50:04 GMT)
--------------------------------------------------

That should be excerpt, not exerpt.

Michael Barnett
Local time: 12:57
Native speaker of: Native in EnglishEnglish
PRO pts in category: 16
Grading comment
Thank you both for kind help!

Peer comments on this answer (and responses from the answerer)
agree  ErichEko ⟹⭐: Yes, determining location of problematic glomerulopathies.
59 mins
  -> Thanks Erich!
agree  kmtext
5 hrs
  -> Thanks kmtext!
agree  William [Bill] Gray: You could replace it with "locating" in the original text; just a more specialist term has been used.
9 hrs
  -> Thanks Bill!
agree  Alfa Trans (X)
11 hrs
  -> Thanks Marju!
agree  Jörgen Slet
22 hrs
  -> Thanks Jorgen!
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