utilities
English translation: health outcome / state of health and resulting quality of life, assessed numerically
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| 08:16 Sep 1, 2014 |
| English language (monolingual) [PRO] Medical - Medical: Health Care / Cost-of-Illness Study in Multiple Sclerosis | |||||||
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|  Selected response from: Charles Davis Spain Local time: 13:34 | ||||||
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| SUMMARY OF ALL EXPLANATIONS PROVIDED | ||||
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| 4 +5 | health outcome / state of health and resulting quality of life, assessed numerically |
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| 4 +1 | cost utilities |
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Answers
55 mins confidence: 
peer agreement (net): +1
peer agreement (net): +1cost utilities Explanation: explained here http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169986/ -------------------------------------------------- Note added at 1 hr (2014-09-01 09:22:47 GMT) -------------------------------------------------- http://ebslgwp.hhs.se/hastef/abs/hastef0459.htm -------------------------------------------------- Note added at 1 hr (2014-09-01 09:26:23 GMT) -------------------------------------------------- from above"..The effectiveness of treatments can be measured in different ways such as disease activity, the number and the severity of relapses or the progression of functional disability, regardless of the type of MS...Also to perform economic evaluations, a global outcome measure is required to capture the impact of treatments on the disease and the most frequently used such measure is quality-adjusted life years (QALYs). However, for QALYs to be used in cost-effectiveness analysis of MS, they must be related to a measure of the disease and disease progression. The Expanded Disability Status Scale (EDSS) provides a good measure of the disease and has been widely used in epidemiological studies and clinical trials, in all types of MS. Lastly, detailed economic data that can be related to the different levels of disability (EDSS) are required..." -------------------------------------------------- Note added at 1 hr (2014-09-01 09:29:29 GMT) -------------------------------------------------- http://www.researchgate.net/publication/8121230_Cost-utility... "..,the model is based on our earlier approach using a Markov model, where disease progression is measured as functional disability (EDSS), costs and utilities associated with different disability levels, and outcome expressed as QALY. " -------------------------------------------------- Note added at 2 hrs (2014-09-01 10:43:52 GMT) -------------------------------------------------- here's another utilities is really about mobility impairment definition here: http://www.plosone.org/article/info:doi/10.1371/journal.pone... "health-related quality of life (HRQoL) (utilities)" |
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2 hrs confidence: peer agreement (net): +5
peer agreement (net): +5health outcome / state of health and resulting quality of life, assessed numerically Explanation: "Utility: In the analysis of health outcomes, a number between 0 and 1 that is assigned to a state of health or an outcome. Perfect health has a utility value of 1. Death has a utility value of 0." http://www.medterms.com/script/main/art.asp?articlekey=5922 So "utility" is a numerical assessment of a person's state of health (and by extention the quality of life), in this case a person with MS. "Utilities", in the plural, refers to the assessment of utility in more than one case (more than one patient, the same patient in different scenarios). "Utility" can be used in this field not only to outcomes not only for the sufferer but also for the caregiver, so it can refer to quality of life. "Instead, the manufacturer obtained health state utility values from Orme et al. (2007), a UK survey of health-related quality of life in (EQ-5D) in people with multiple sclerosis. Utility values decreased as EDSS scores increased, with the exception of the utility value for EDSS state 3, which was lower than EDSS 4. EDSS states 8 and 9 had negative utility values, indicating states that are considered to be worse than being dead. The manufacturer applied disutilities for a relapse, to caregivers, and for adverse events" (p. 13) http://www.nice.org.uk/guidance/ta312/resources/multiple-scl... |
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