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establish the risk of the disease

English translation: determine the disease risk/risk of the disease

11:17 Sep 18, 2005
English language (monolingual) [PRO]
Science - Genetics / epidemiology/multifactorial diseases
English term or phrase: establish the risk of the disease
Is *establish* appropriate here ?

Since I'm at it, does anyone feel that there is something wrong with the logical content of this paragraph ?

The combined distribution of these genetic determinants in different populations, and the exposure to such environmental factors, follow highly complex patterns with considerable variation. Because each individual is characterized by a specific range of genetic features and environmental exposures, his/her risk of developing a multifactorial disease is patterned after complex statistical relationships. These relationships, which **establish** the risk of the disease (at birth or according to age) are imprecisely described by the statistical models currently in in use.

Thanks for your help
Linda 969
Local time: 05:17
Selected answer:determine the disease risk/risk of the disease
Explanation:
The majority of neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson'ss disease (PD), are genetically complex. While several potential factors have been described, which may determine the disease risk, genetic factors play the most important role.
http://www3.interscience.wiley.com/cgi-bin/abstract/98517304...

http://www.google.com/search?hl=en&lr=&rls=GGLD,GGLD:2005-06...

Relative risk, attributable risk
These are some of the more common measures of association (MA). A MA is any mathematical measure that is used to quantify the association between two or more variables; thus, it is a measure of the extent to which variables X and Y are related.

Attributable Risks (AR) are a group of measures which describe the amount of disease risk that can be attributed to a given factor X. One of the most common AR measures is the Attributable Fraction, which is the proportion of disease Y in the population that can be attributed to factor X. It is computed as follows:
[(Incidence in population) - (Incidence in unexposed group)]/ (Incidence in population)


http://www.collegeboard.com/yes/ae/gloss.html
Selected response from:

Elena Petelos
United Kingdom
Local time: 04:17
Grading comment
my thanks to everyone ;-)
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
5 +6determine the disease risk/risk of the disease
Elena Petelos
4 +1establish the degree of risk of the disease
Jack Doughty
4determine the risk of the disease
Piotr Sawiec
4Translation below...
gavinlucas


Discussion entries: 5





  

Answers


4 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
establish the degree of risk of the disease


Explanation:
I think it's all right as it is really, but as the statistics must be indicating the degree of risk, rather than just showing risk/no risk, degree of risk might be clearer.

Jack Doughty
United Kingdom
Local time: 04:17
Native speaker of: English

Peer comments on this answer (and responses from the answerer)
agree  Jörgen Slet: "degree" is clearer, but it's often omitted
8 hrs
  -> Thank you.
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15 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
determine the risk of the disease


Explanation:
as far as I understand, the risk depends on interactions between various factors, so in this case I would use "determine"

Piotr Sawiec
Local time: 05:17
Specializes in field
Native speaker of: Native in PolishPolish
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15 mins   confidence: Answerer confidence 5/5 peer agreement (net): +6
determine the disease risk/risk of the disease


Explanation:
The majority of neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson'ss disease (PD), are genetically complex. While several potential factors have been described, which may determine the disease risk, genetic factors play the most important role.
http://www3.interscience.wiley.com/cgi-bin/abstract/98517304...

http://www.google.com/search?hl=en&lr=&rls=GGLD,GGLD:2005-06...

Relative risk, attributable risk
These are some of the more common measures of association (MA). A MA is any mathematical measure that is used to quantify the association between two or more variables; thus, it is a measure of the extent to which variables X and Y are related.

Attributable Risks (AR) are a group of measures which describe the amount of disease risk that can be attributed to a given factor X. One of the most common AR measures is the Attributable Fraction, which is the proportion of disease Y in the population that can be attributed to factor X. It is computed as follows:
[(Incidence in population) - (Incidence in unexposed group)]/ (Incidence in population)


http://www.collegeboard.com/yes/ae/gloss.html


Elena Petelos
United Kingdom
Local time: 04:17
Specializes in field
Native speaker of: Greek
PRO pts in category: 8
Grading comment
my thanks to everyone ;-)

Peer comments on this answer (and responses from the answerer)
agree  RHELLER: hi Elena!
2 hrs
  -> Hello you! ;-))
agree  Elizabeth Rudin
2 hrs
  -> Thanks!
agree  humbird: I come across "determine" most often in this kind of literature.
4 hrs
  -> Thanks!
agree  Alfa Trans (X)
4 hrs
  -> :-)
agree  Jörgen Slet: "determine the disease risk" sounds best to me
8 hrs
  -> :-)
agree  Dr Sue Levy (X): how's that MPH going? :-))
9 hrs
  -> :-)) MPH starting in 2 weeks, still undecided, but decided on two other points. :-)))))
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902 days   confidence: Answerer confidence 4/5Answerer confidence 4/5
Translation below...


Explanation:
Hi Linda,
I think you're right that it has a readability problem! I would write it like this:

The distribution of these genetic determinants in different populations, and the patterns of exposure to such environmental factors, are complex and highly variable. Since each individual has a different profile of genetic risk factors and environmental exposures, his/her risk of developing a complex, multifactorial disease can only be estimated using complex statistical modelling. However, current statistical models are incapable of accurately estimating lifetime or age-related risk of disease.

Gavin

gavinlucas
Local time: 05:17
Specializes in field
Native speaker of: Native in EnglishEnglish
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