RET

Spanish translation: RET — REarranged during Transfección > REordenado durante la Transfección

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:RET
Spanish translation:RET — REarranged during Transfección > REordenado durante la Transfección
Entered by: Charles Davis

16:27 Sep 29, 2018
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / Investigator\'s Brochure (Preclinical pharmacology)
English term or phrase: RET
Hola a todos:
Estoy traduciendo el manual de investigador de un fármaco y en esta parte menciona quinasas/cinasas. Algunas están incluidas en la lista de abreviaturas pero no es el caso de RET.
El texto dice lo siguiente:

Preclinical pharmacology

(DRUG) was first discovered as an inhibitor of several protein kinase C (PKC) isoforms. It is now established that (DRUG) and two major circulating metabolites are multi-targeted protein kinase inhibitors with activity against mutant forms of FLT3 and KIT, as well as several kinases involved in their signaling pathways or otherwise implicated in acute myeloid leukemia (AML), such as via stromal support, including AURK, IGF1R, JAK, LYN, PDPK1, PIM1, RET, SYK and VEGFR2. (DRUG) binds to the catalytic domain of these kinases and inhibits the mitogenic signaling of the respective growth factors in cells and results in growth arrest.

Alguna sugerencia?
Desde ya muchas gracias!
Belén Nieto
Local time: 12:46
RET — REarranged during Transfección > REordenado durante la Transfección
Explanation:
En español se emplea RET tal cual. Si necesitas saber qué significa la sigla, es esto.

"The RET (REarranged during Transfection) proto-oncogene, situated on chromosome sub-band 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest. RET is a receptor tyrosine kinase involved in cell proliferation, neuronal navigation, cell migration, and cell differentiation."
http://tcr.amegroups.com/article/view/16196/html

"En su estudio, el Dr. Knight y el equipo señalan que un tipo de RTK – re-ordenado durante la transfección (RET) – está regulado positivamente en las células madre formadoras de músculo, o mioblastos, que expresan una proteína llamada DUX4. Esta proteína está codificada por el gen DUX4, situado en la región D4Z4 implicada en la FSHD."
http://fshd-spain.org/2016/12/23/farmaco-contra-el-cancer-pu...

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Note added at 43 mins (2018-09-29 17:10:40 GMT)
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"Identificación de los mecanismos moleculares que median la función de la proteína Gas1 a través del receptor tirosina quinasa Ret"
https://repositorio.uam.es/handle/10486/663518

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Note added at 45 mins (2018-09-29 17:12:23 GMT)
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" Receptor tyrosine kinases:

Receptor tyrosine kinases (RTKs), a family of cell-surface receptors, which transduce signals to polypeptide and protein hormones, cytokines and growth factors are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism, cell migration and cell cycle control [1-2,4]. In the human genome, 58 RTKs have been identified, which fall into 20 families [3]. [...]
Type XIV RTKs: RET"
https://www.genenames.org/cgi-bin/genefamilies/set/321
Selected response from:

Charles Davis
Spain
Local time: 17:46
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +2RET — REarranged during Transfección > REordenado durante la Transfección
Charles Davis
Summary of reference entries provided
Ret
Chema Nieto Castañón

  

Answers


41 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
ret
RET — REarranged during Transfección > REordenado durante la Transfección


Explanation:
En español se emplea RET tal cual. Si necesitas saber qué significa la sigla, es esto.

"The RET (REarranged during Transfection) proto-oncogene, situated on chromosome sub-band 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest. RET is a receptor tyrosine kinase involved in cell proliferation, neuronal navigation, cell migration, and cell differentiation."
http://tcr.amegroups.com/article/view/16196/html

"En su estudio, el Dr. Knight y el equipo señalan que un tipo de RTK – re-ordenado durante la transfección (RET) – está regulado positivamente en las células madre formadoras de músculo, o mioblastos, que expresan una proteína llamada DUX4. Esta proteína está codificada por el gen DUX4, situado en la región D4Z4 implicada en la FSHD."
http://fshd-spain.org/2016/12/23/farmaco-contra-el-cancer-pu...

--------------------------------------------------
Note added at 43 mins (2018-09-29 17:10:40 GMT)
--------------------------------------------------

"Identificación de los mecanismos moleculares que median la función de la proteína Gas1 a través del receptor tirosina quinasa Ret"
https://repositorio.uam.es/handle/10486/663518

--------------------------------------------------
Note added at 45 mins (2018-09-29 17:12:23 GMT)
--------------------------------------------------

" Receptor tyrosine kinases:

Receptor tyrosine kinases (RTKs), a family of cell-surface receptors, which transduce signals to polypeptide and protein hormones, cytokines and growth factors are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism, cell migration and cell cycle control [1-2,4]. In the human genome, 58 RTKs have been identified, which fall into 20 families [3]. [...]
Type XIV RTKs: RET"
https://www.genenames.org/cgi-bin/genefamilies/set/321

Charles Davis
Spain
Local time: 17:46
Native speaker of: Native in EnglishEnglish
PRO pts in category: 64
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  Chema Nieto Castañón
25 mins
  -> Muchas gracias, Chema :-)

agree  JohnMcDove
5 hrs
  -> Muchas gracias, John :-)
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Reference comments


1 hr
Reference: Ret

Reference information:
Ret es el Receptor Tirosina Quinasa (RTK) para los factores neurotróficos de la familia de GDNF, que median supervivencia, diferenciación, migración o ...
https://www.google.es/url?sa=t&source=web&rct=j&url=https://...

Análisis de los receptores tirosina quinasa ALK, RET y ROS en los adenocarcinomas nasosinusales
https://www.google.es/url?sa=t&source=web&rct=j&url=http://d...

Chema Nieto Castañón
Spain
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 490
Login to enter a peer comment (or grade)



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