PIM1

Spanish translation: (quinasa) pim1

16:24 Sep 29, 2018

English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / Investigator\'s Brochure (Preclinical pharmacology)

English term or phrase: PIM1

Hola a todos:
Estoy traduciendo el manual de investigador de un fármaco y en esta parte menciona quinasas/cinasas. Algunas están incluidas en la lista de abreviaturas pero no es el caso de PIM1.
El texto dice lo siguiente:

Preclinical pharmacology

(DRUG) was first discovered as an inhibitor of several protein kinase C (PKC) isoforms. It is now established that (DRUG) and two major circulating metabolites are multi-targeted protein kinase inhibitors with activity against mutant forms of FLT3 and KIT, as well as several kinases involved in their signaling pathways or otherwise implicated in acute myeloid leukemia (AML), such as via stromal support, including AURK, IGF1R, JAK, LYN, PDPK1, PIM1, RET, SYK and VEGFR2. (DRUG) binds to the catalytic domain of these kinases and inhibits the mitogenic signaling of the respective growth factors in cells and results in growth arrest.

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Desde ya muchas gracias!

Belén Nieto KudoZ activity Questions: 295 (10 open) (2 without valid answers) (52 closed without grading) Answers: 0
Local time: 05:40

Spanish translation:(quinasa) pim1

Explanation:
Pim1 hace referencia a un gen. La denominación quinasa pim1 (también serina/treonina quinasa) mantiene el nombre pim1 original en alusión a dicho gen.

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene
https://en.m.wikipedia.org/wiki/PIM1

c-myb, bcl-2, pim-1 y c-raf-1 y el gen de la tirosina quinasa Itk son inducidos
https://books.google.es/books?id=4it1kNfmSu0C&pg=PA21&lpg=PA...

proteína asociada a la kinasa PIM1
https://books.google.es/books?id=Qc21l4mApbAC&pg=PA82&lpg=PA...

Selected response from:

Chema Nieto Castañón
Spain
Local time: 10:40

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(quinasa) pim1

Chema Nieto Castañón

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pim1

(quinasa) pim1

Chema Nieto Castañón
Spain
Local time: 10:40
Specializes in field
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Spanish
PRO pts in category: 553

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