PIM1

Spanish translation: (quinasa) pim1

16:24 Sep 29, 2018
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / Investigator\'s Brochure (Preclinical pharmacology)
English term or phrase: PIM1
Hola a todos:
Estoy traduciendo el manual de investigador de un fármaco y en esta parte menciona quinasas/cinasas. Algunas están incluidas en la lista de abreviaturas pero no es el caso de PIM1.
El texto dice lo siguiente:

Preclinical pharmacology

(DRUG) was first discovered as an inhibitor of several protein kinase C (PKC) isoforms. It is now established that (DRUG) and two major circulating metabolites are multi-targeted protein kinase inhibitors with activity against mutant forms of FLT3 and KIT, as well as several kinases involved in their signaling pathways or otherwise implicated in acute myeloid leukemia (AML), such as via stromal support, including AURK, IGF1R, JAK, LYN, PDPK1, PIM1, RET, SYK and VEGFR2. (DRUG) binds to the catalytic domain of these kinases and inhibits the mitogenic signaling of the respective growth factors in cells and results in growth arrest.

Alguna sugerencia?
Desde ya muchas gracias!
Belén Nieto
Local time: 00:14
Spanish translation:(quinasa) pim1
Explanation:
Pim1 hace referencia a un gen. La denominación quinasa pim1 (también serina/treonina quinasa) mantiene el nombre pim1 original en alusión a dicho gen.

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene
https://en.m.wikipedia.org/wiki/PIM1

c-myb, bcl-2, pim-1 y c-raf-1 y el gen de la tirosina quinasa Itk son inducidos
https://books.google.es/books?id=4it1kNfmSu0C&pg=PA21&lpg=PA...

proteína asociada a la kinasa PIM1 
https://books.google.es/books?id=Qc21l4mApbAC&pg=PA82&lpg=PA...
Selected response from:

Chema Nieto Castañón
Spain
Local time: 05:14
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2(quinasa) pim1
Chema Nieto Castañón


Discussion entries: 1





  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
pim1
(quinasa) pim1


Explanation:
Pim1 hace referencia a un gen. La denominación quinasa pim1 (también serina/treonina quinasa) mantiene el nombre pim1 original en alusión a dicho gen.

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene
https://en.m.wikipedia.org/wiki/PIM1

c-myb, bcl-2, pim-1 y c-raf-1 y el gen de la tirosina quinasa Itk son inducidos
https://books.google.es/books?id=4it1kNfmSu0C&pg=PA21&lpg=PA...

proteína asociada a la kinasa PIM1 
https://books.google.es/books?id=Qc21l4mApbAC&pg=PA82&lpg=PA...

Chema Nieto Castañón
Spain
Local time: 05:14
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 494
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  Charles Davis: En inglés, PiM = Protease inhibitor (type) M.
8 mins
  -> Muchas gracias por el apunte, Charles! Buen finde!

agree  Yailen del Pino
33 mins
  -> Gracias, Yailen
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