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Chirally controlled oligonucleotide composition

14:17 Sep 3, 2020
This question was closed without grading. Reason: Other

English to Russian translations [PRO]
Law/Patents - Biology (-tech,-chem,micro-) / Синтетические олигонуклеотиды
English term or phrase: Chirally controlled oligonucleotide composition
The terms "chirally controlled (stereocontrolled or stereodefined) oligonucleotide composition", "chirally controlled (stereocontrolled or stereodefined) nucleic acid composition", and the like, as used herein, refers to a composition that comprises a plurality of oligonucleotides (or nucleic acids, chirally controlled oligonucleotides or chirally controlled nucleic acids) which share 1) a common base sequence, 2) a common pattern of backbone linkages; 3) a common pattern of backbone chiral centers, and 4) a common pattern of backbone phosphorus modifications (oligonucleotides of a particular type), wherein the plurality of oligonucleotides (or nucleic acids) share the same stereochemistry at one or more chiral internucleotidic linkages (chirally controlled internucleotidic linkages, whose chiral linkage phosphorus is Rp or Sp, not a random Rp and Sp mixture as non-chirally controlled internucleotidic linkages).

As used herein, "chiral control" refers to control of the stereochemical designation of a chiral linkage phosphorus in a chiral internucleotidic linkage within an oligonucleotide.
In some embodiments, a control is achieved through a chiral element that is absent from the sugar and base moieties of an oligonucleotide, for example, in some embodiments, a control is achieved through use of one or more chiral auxiliaries during oligonucleotide preparation as exemplified in the present disclosure, which chiral auxiliaries often are part of chiral phosphoramidites used during oligonucleotide preparation.



Композиция на основе олигонуклеотида (олигонуклеотидная композиция) с контролируемой хиральностью? Хотя мой первый вариант был с заданной хиральностью - по аналогии с ответом на схожий вопрос (https://www.proz.com/kudoz/english-to-russian/genetics/61698...

вот иллюстрация для данной технологии.
https://mosmedpreparaty.ru/wp-content/uploads/2018/02/wave-l...
https://mosmedpreparaty.ru/news/10971

Спасибо!
Wolfskin
Local time: 23:43


Summary of answers provided
3Олигонуклеотидная композиция с контролируемым стереоизомерным составом
Igor Andreev


Discussion entries: 1





  

Answers


20 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
chirally controlled oligonucleotide composition
Олигонуклеотидная композиция с контролируемым стереоизомерным составом


Explanation:
М.б. так переиначить, поскольку кажется имели в виду именно это
Хиральность - свойство молекулы, как ее контролировать?

Igor Andreev
Local time: 23:43
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 1427
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