This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
  1. KudoZ™ Top
  2. English to Russian
  3. Biology (-tech,-chem,micro-)

is directed internally in the transcript

Russian translation: (трансляция) управляется внутренними регуляторными последовательностями транскрипта

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:is directed internally in the transcript
Russian translation:(трансляция) управляется внутренними регуляторными последовательностями транскрипта
Entered by: Nitrogen

09:01 Aug 15, 2019
English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-) / геентика�
English term or phrase: is directed internally in the transcript
To increase efficiency of production, the polynucleotide can be designed to encode multiple units of the single or multi-domain peptide separated by enzymatic cleavage sites. The resulting polypeptide can be cleaved (e.g., by treatment with the appropriate enzyme) in order to recover the peptide units. This can increase the yield of peptides driven by a single promoter. In some embodiments, a polycistronic polynucleotide can be designed so that a single mRNA is transcribed which encodes multiple peptides, each coding region operatively linked to a cap-independent translation control sequence, for example, an internal ribosome entry site (IRES). When used in appropriate viral expression systems, the translation of each peptide encoded by the mRNA ***is directed internally in the transcript***, for example, by the IRES. Thus, the polycistronic construct directs the transcription of a single, large polycistronic mRNA which, in turn, directs the translation of multiple, individual peptides. This approach eliminates the production and enzymatic processing of polypeptides and can significantly increase yield of peptide driven by a single promoter.
Nitrogen
Local time: 00:59
(трансляция) управляется внутренними регуляторными последовательностями транскрипта
Explanation:
Когда в одном транскрипте несколько кодирующих последовательностей, то перед каждой расположены свои регуляторные последовательности, с которыми связывается рибосома. Таким образом, трансляция может начинаться не только с 5'-конца транскрипта, но и с внутренних участков.
Selected response from:

Tatiana Nikitina
Russian Federation
Local time: 00:59
Grading comment
Большое спасибо
4 KudoZ points were awarded for this answer



Summary of answers provided
5(трансляция) управляется внутренними регуляторными последовательностями транскрипта
Tatiana Nikitina


  

Answers


30 mins   confidence: Answerer confidence 5/5
(трансляция) управляется внутренними регуляторными последовательностями транскрипта


Explanation:
Когда в одном транскрипте несколько кодирующих последовательностей, то перед каждой расположены свои регуляторные последовательности, с которыми связывается рибосома. Таким образом, трансляция может начинаться не только с 5'-конца транскрипта, но и с внутренних участков.

Tatiana Nikitina
Russian Federation
Local time: 00:59
Specializes in field
Native speaker of: Russian
PRO pts in category: 503
Grading comment
Большое спасибо
Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:
ProZ.com term search
Search millions of term translations
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search