membrane pacemaker theory
Italian translation: teoria della membrana come pacemaker metabolico/del ruolo di pacemaker metabolico della membrana
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| 10:01 May 31, 2015 |
| English to Italian translations [PRO] Medical - Biology (-tech,-chem,micro-) / teorie sull'invecchiamento | |||||||
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|  Selected response from: Francesco Paolo Jori Portugal Local time: 06:59 | ||||||
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25 mins confidence: 
peer agreement (net): +1
peer agreement (net): +1teoria della membrana come pacemaker metabolico/del ruolo di pacemaker metabolico della membrana Explanation: Non credo che esista una traduzione ufficiale, ma la spiegazione della teoria la trovi qui: http://www.ncbi.nlm.nih.gov/pubmed/17464520 Membrane fatty acids as pacemakers of animal metabolism. Hulbert AJ1. The recent discovery that the fatty acid composition of tissue phospholipids varies in a systematic manner among species has lead to the proposal that membrane fatty acid composition is an important determinant of the metabolic rate characteristic for each species. Endotherms (mammals and birds) have a basal metabolic rate (BMR) that is several times that of ectotherms and have more polyunsaturated membranes. In both birds and mammals, as species size increases there is a decrease in mass-specific BMR and a decrease in membrane polyunsaturation. Membrane-associated processes are significant components of BMR and important membrane proteins operate at much faster rates in species with high BMR than in those with low BMR. A series of "species-crossover" experiments show that the rate of this molecular activity is largely due to the nature of the membrane bilayer surrounding these membrane proteins such that polyunsaturated membranes are associated with fast membrane-associated processes. It is suggested that this influence is due to the physical properties that such polyunsaturated membranes possess. This has been called the **membrane pacemaker theory** of metabolism and provides a framework to understand factors such as the influence of diet on metabolism. In italiano trovi vari riferimenti per "membrana" e "pacemaker metabolico": Un punto di osservazione molto importante è la MEMBRANA CELLULARE, che è un compartimento cellulare con numerosi compiti strutturali e funzionali ben conosciuti, ma venuta ancor più alla ribalta per il suo ruolo di pacemaker metabolico. www.lipinutragen.it/wp-content/uploads/.../Lipidomica-Gravi... La membrana cellulare è il “pacemaker metabolico” ovvero ricopre il ruolo di regolatore di scambi e di segnalazioni che sono cruciali www.alessandroprota.it/crema-buwig/ Quindi secondo me conviene trovare un modo sintetico di esprimere il concetto, te no ho suggeriti un paio, ma magari trovi una forma migliore di esprimerlo. |
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6 hrs confidence:
il doppio strato lipidico delle membrane cellulari è coinvolto in diversi meccanismi metabolici Explanation: la teoria postula che i processi molecolari che avvengono a livello della membrana cellulare sono coinvolti nel metabolismo cellulare, soprattutto in virtù della componente "acilica" del doppio strato lipidico. Quindi teoria della "membrana come regolatore metabolico". Anche io lascerei "teoria della membrana cellulare come pacemaker metabolico" Membrane bilayers are essential elements of life, and the synthesis of the hydrocarbons that make up membrane bilayers may have preceded the appearance of life on Earth. Membrane-associated processes are significant components of metabolism, and the acyl composition of membrane bilayers is associated with metabolic activity in a predictable manner. This has resulted in the "membrane pacemaker" theory of metabolism, which proposes that the relative balance between monounsaturated and long-chain polyunsaturated acyl chains in membrane bilayers is a fundamental determinant of metabolic rate of a species. Reference: http://www.ncbi.nlm.nih.gov/pubmed/12796449 |
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