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  3. Biology (-tech,-chem,micro-)

gene silencing

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13:58 Feb 9, 2010
English to Indonesian translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics
English term or phrase: gene silencing
Definition from MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Example sentence(s):
  • Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. biotech-info.net
  • The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
  • In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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Summary of translations provided
5pembungkaman gen
Wiyanto Suroso
4 +1Peredaman gen
qbenk4u


  

Translations offered


5 days   confidence: Answerer confidence 5/5
pembungkaman gen


Definition from MedicineNet, Inc.:
Pembungkaman gen ialah mekanisme ketika sel-sel menutup sebagian besar DNA khromosom.

Example sentence(s):
  • Publikasi tersebut menunjukkan teknik pembungkaman gen pada tumbuhan dalam mekanisme pertahanan terhadap virus, dan jelas menggambarkan penelitian pembungkaman gen pada tumbuhan selangkah lebih dahulu dibandingkan penelitian pembungkaman gen pada hewan dengan model pada cacing C. elegans yang digunakan oleh Fire dan Mello beserta kolega-koleganya. - Kamus Ilmiah  
  • Semakin banyak jumlah salinan gen yang disisipkan maka ekspresi gen kurang stabil akibat dari adanya pembungkaman gen dan proses penyusunan kembali (rearrangement) semakin tinggi yang mengakibatkan ekspresi gen kurang stabil (Dai et al. 2001). - ANEKAPLANTASIA.cybermediaclip  
  • Integrasi dan ekspresi gen masih belum jelas dimengerti. Cao et al. (2004) menyarankan penggunaan promoter yang berbeda untuk masing-masing kaset ekspresi, untuk menghindari terjadinya pembungkaman gen pada tahap transkripsi (transcriptional silencing). - Anak Belitang  

Explanation:
Pembungkaman gen disebut juga dengan peredaman gen.
Wiyanto Suroso
Indonesia
Local time: 04:54
Native speaker of: Native in IndonesianIndonesian
PRO pts in category: 17
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77 days   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
Peredaman gen


Definition from Wikipedia:
Sebagai padanan gene silencing, mengacu pada sejumlah metode yang dipakai dalam biologi molekular untuk menghalangi/meredam ekspresi gen memanipulasi bahan genetik secara terkendali. Dengan demikian, penggunaan mutagen seperti sinar radioaktif atau penggunaan bahan kimia per se tidak termasuk di dalamnya. Peredaman ekspresi gen dapat dilakukan pada tingkat DNA maupun RNA (lihat ekspresi genetik).

Example sentence(s):
  • Tahap-tahap penting berikutnya adalah serangkaian penemuan enzim restriksi (pemotong) DNA, regulasi (pengaturan ekspresi) DNA (diawali dari penemuan operon laktosa pada prokariota ), perakitan teknik PCR , transfprmasi genetik , teknik peredaman gen (termasuk interferensi RNA), dan teknik mutasi terarah (seperti Tilling) - Warta Gunadarma  

Explanation:
Mempertegas penjelasan dari pak Wiyanto, hanya urutanya saja yang berbeda padanan kata 'Gene silencing', 'pembungkaman gen', dan 'pemadaman gen' beralih ke peredaman gen. Menurut Wikipedia, istilah dalam bahasa Indonesia ini dipilih karena paling mendekati makna istilah asli dan makna teknisnya
qbenk4u
Local time: 04:54
Native speaker of: Native in IndonesianIndonesian

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Amin Masruri
587 days
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