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vitamin k-dependent plasma glycoprotein

German translation: Vitamin-K-abhängiges Glykoprotein

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00:54 May 17, 2020
English to German translations [PRO]
COVID-19 - Science - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical (general), Journalism
English term or phrase: vitamin k-dependent plasma glycoprotein
Definition from Science Direct:
Vitamin K–dependent proteins, synthesized in the liver, play a central role in blood coagulation through either procoagulant or anticoagulant mechanisms. The vitamin K–dependent protein family includes the zymogen procoagulant factors VII, IX, X, and prothrombin, and the anticoagulants protein C, protein S, and protein Z

Example sentence(s):
  • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. National Center for Biotechnology Info.
  • Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Research Gate
  • Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. The JBC
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


This question is closed

German translation:Vitamin-K-abhängiges Glykoprotein
Definition:
oder auch: Vitamin-K-abhängiges Plasmaglykoprotein

Plasmaproteine bezeichnen die Blutproteine, die am häufigsten im Blutplasma vorkommen. Dazu zählen unter anderem Glykoproteine, Lipoproteine und Metalloproteine.

Vitamin K ist ein Cofaktor der bei der Bildung mehrerer Gerinnungsfaktoren in der Leber durch die y-Carboxylierung von Glutamylresten beteiligt ist.
Selected response from:

Isabella Hansmann, MSc, MA
Spain
Grading comment
4 KudoZ points were awarded for this answer



Summary of translations provided
4 +3Vitamin-K-abhängiges Glykoprotein
Isabella Hansmann, MSc, MA


  

Translations offered


6 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
Vitamin-K-abhängiges Glykoprotein


Definition from own experience or research:
oder auch: Vitamin-K-abhängiges Plasmaglykoprotein

Plasmaproteine bezeichnen die Blutproteine, die am häufigsten im Blutplasma vorkommen. Dazu zählen unter anderem Glykoproteine, Lipoproteine und Metalloproteine.

Vitamin K ist ein Cofaktor der bei der Bildung mehrerer Gerinnungsfaktoren in der Leber durch die y-Carboxylierung von Glutamylresten beteiligt ist.

Example sentence(s):
  • Protein C, ein Vitamin-K-abhängiges Glykoprotein, wird durch den Thrombin-Thrombomodulin-Komplex zu aktiviertem Protein C (APC) umgewandelt, welches in Gegenwart seines Cofaktors, Protein S, selektiv die Gerinnungsfaktoren Faktor VIII und Faktor V hemmt, wodurch das prokoagulatorische System reguliert wird. - Springer Link  
  • Protein Z ist ein Vitamin K-abhängiges Glykoprotein, das als Cofaktor für die Inaktivierung von FXa durch das Serpin "Protein-Z-abhängiger Proteinaseinhibitor (ZPI)" beschleunigt. - Lexikon der Mediz. Laboratoriumsdiag.  
  • Faktor VII (FVII) ist ein Vitamin-K-abhängiges Glykoprotein, das in der Leber synthetisiert und ins Blut abgegeben wird. - Medizinische Genetik  
Isabella Hansmann, MSc, MA
Spain
Local time: 15:50
Native speaker of: Native in GermanGerman
PRO pts in category: 40

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Edith Kelly
45 mins
Yes  Steffen Walter
2 hrs
Yes  gofink
4 hrs
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