affinity maturation

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00:54 Oct 28, 2020
English to Bulgarian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5съзряване на афинитета
Emilia Balke


  

Translations offered


1 hr   confidence: Answerer confidence 5/5
съзряване на афинитета


Definition from own experience or research:
Процес, при който лимфоцити, които по-късно се развиват и стават плазмени клетки, съзряват и произвеждат антитела, които имат по-голям афинитет към клетките на антигана, с който се борят.

Example sentence(s):
  • Тези опасения произтичат от идеята, че епитопът е повърхност, дефинирана от mAb, която е преминала през уникален процес на селекция на BCR и еволюционно съзряване на афинитета, и поради стохастичния характер на генериране и съзряване на Ab, представяне на същата повърхност на имунитета системата няма да доведе до индуциране на един и същ уникален вид Ab [68, 69]. - Разработване на профи  
Emilia Balke
United States
Local time: 05:34
Native speaker of: Native in BulgarianBulgarian, Native in EnglishEnglish
PRO pts in category: 8
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