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Pro-Myelocytic Leukaemia/Retinoic-Acid-Receptor-alpha (PML/RAR-alpha) gene

Russian translation: см.

05:18 Jul 3, 2020
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals / PRAC PSUR assessment report
English term or phrase: Pro-Myelocytic Leukaemia/Retinoic-Acid-Receptor-alpha (PML/RAR-alpha) gene
In the EU, Trisenox (arsenic trioxide or ATO) is indicated for induction of remission, and consolidation in adult patients with:
- Newly diagnosed low-to-intermediate risk acute promyelocytic leukaemia (APL) (white blood cell count, ≤10 x 103/μl) in combination with all-trans-retinoic acid (ATRA)
- Relapsed/refractory acute promyelocytic leukaemia (APL) (Previous treatment should have included a retinoid and chemotherapy)
characterised by the presence of the t(15;17) translocation and/or the presence of the Pro-Myelocytic Leukaemia/Retinoic-Acid-Receptor-alpha (PML/RAR-alpha) gene.
Julia Berezina
Local time: 02:32
Russian translation:см.
Explanation:
химерный/гибридный ген PML-RARa, образовавшийся в результате слияния гена промиелоцитарного лейкоза и гена альфа-рецептора ретиноевой кислоты
Selected response from:

Igor Andreev
Local time: 02:32
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4ген промиелоцитарного лейкоза с вовлечением рецептора ретиноевой кислоты типа альфа
Alexander Smirnow
4см.
Igor Andreev


  

Answers


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5
ген промиелоцитарного лейкоза с вовлечением рецептора ретиноевой кислоты типа альфа


Explanation:
Эта форма ОМЛ характеризуется типичной хромосомной транслокацией, вовлекающей ген рецептора ретиноевой кислоты типа альфа (RARα или RARA) и ген белка острого промиелоцитарного лейкоза (PML).

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Note added at 1 hr (2020-07-03 06:50:15 GMT)
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Что-то ссылка сломалась. Вот нормальная.

ru.wikipedia.org/wiki/Острый_миелоидный_лейкоз


    https://ru.wikipedia.org/wiki/%D0%9E%D1%81%D1%82%D1%80%D1%8B%D0%B9_%D0%BF%D1%80%D0%BE%D0%BC%D0%B8%D0%B5%D0%BB%D0%BE%D1%86%D0%B8%D1%82%D0%B0%
Alexander Smirnow
Russian Federation
Native speaker of: Russian
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2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
pro-myelocytic leukaemia/retinoic-acid-receptor-alpha (pml/rar-alpha) gene
см.


Explanation:
химерный/гибридный ген PML-RARa, образовавшийся в результате слияния гена промиелоцитарного лейкоза и гена альфа-рецептора ретиноевой кислоты

Igor Andreev
Local time: 02:32
Native speaker of: Native in RussianRussian
PRO pts in category: 625
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