MMR proficient
Polish translation: bez niedoboru naprawy niesparowanych zasad
| 14:33 Jun 4, 2020 |
| English to Polish translations [PRO] Medical - Medical (general) / rehabilitation | |||||||
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|  Selected response from: smerfetka1 Local time: 20:55 | ||||||
Grading comment
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| Summary of answers provided | ||||
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| 4 | bez niedoboru naprawy niesparowanych zasad |
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| 3 | zdolność komórki do naprawy własnego DNA |
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| Summary of reference entries provided | |||
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| DNA MMR deficiency |
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Answers
4 hrs confidence: 
zdolność komórki do naprawy własnego DNA Explanation: Defective DNA mismatch repair (MMR) occurs in approximately 15% of sporadic colorectal cancers (CRCs). MMR-proficient tumors include those that are micro satellite stable (MSS) and MSI-low (MSI-L) or tumors with intact MMR proteins. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767984/#:~:tex... cccccccc mismatch repair deficiency listen (MIS-match reh-PAYR deh-FIH-shun-see) Describes cells that have mutations (changes) in certain genes that are involved in correcting mistakes made when DNA is copied in a cell. Mismatch repair (MMR) deficient cells usually have many DNA mutations, which may lead to cancer. MMR deficiency is most common in colorectal cancer, other types of gastrointestinal cancer, and endometrial cancer, but it may also be found in cancers of the breast, prostate, bladder, and thyroid. MMR deficiency may also be found in an inherited disorder called Lynch syndrome. Knowing if a tumor is MMR deficient may help plan treatment or predict how well the tumor will respond to treatment. https://www.cancer.gov/publications/dictionaries/cancer-term... cccccccccc Nasze komórki wykształciły w drodze ewolucji mechanizmy, które korygują błędy zachodzące w procesie replikacji DNA. W przypadku zakłócenia procesu naprawy DNA (MMR) utrzymanie stabilności genomu jest zagrożone, co staje się źródłem mutacji powodujących choroby, takie jak rak. https://cordis.europa.eu/article/id/90346-dna-repair-process... ccccc naprawa niesparowanych zasad (MMR, ang. mismatch repair) koryguje błędy zaistniałe przy replikacji i rekombinacji genów, powodujące powstawanie niesparowanych zasad. Uszkodzenie obu nici Zdolność komórki do naprawy własnego DNA -------------------------------------------------- Note added at 4 hrs (2020-06-04 19:06:09 GMT) -------------------------------------------------- https://pl.wikipedia.org/wiki/Naprawa_DNA ccccccccccccccccccccccccccccccccc |
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1 day 1 hr confidence:
bez niedoboru naprawy niesparowanych zasad Explanation: . Example sentence(s):
https://www.termedia.pl/Badanie-molekularnych-markerow-wykorzystywanych-w-leczeniu-chorych-na-raka-jelita-grubego,60,24619,1,0.html Reference: http://www.naukowy.pl/medycyna/proces-naprawy-dna-a-problem-... |
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Notes to answerer
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Reference comments
48 mins |
| Reference: DNA MMR deficiency Reference information: DNA MMR deficiency is one of the best known and studied genetic causes of colorectal cancer. It can impact treatment decisions and outcomes for colorectal cancer patients, and individuals and their family members who have this mutation may be at risk for additional cancers. |
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