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embryonic lineage and developmental origin

Russian translation: эмбриональное происхождение

20:20 May 16, 2020
English to Russian translations [PRO]
Medical - Medical (general) / Гистология, эмбриология
English term or phrase: embryonic lineage and developmental origin
Исследовали влияние андрогенов на адипогенез и остеогенез.

These observations reveal the opposing effects of androgen signaling on lineage commitment and osteoblast differentiation that is enhanced in cells derived from a neural crest origin but inhibited in cells derived from a mesodermal origin, consistent with in vivo compartment-specific responses to androgen. Combined, these results highlight the complex action of androgen in the body that is dependent on the embryonic lineage and developmental origin of the cell.

Перед этим:
Multipotent fraction 1 progenitor populations from both genotypes were cultured separately as frontal bone neural crest stem-like cells (fNCSC) and parietal bone mesenchymal stem-like cells (pMSC). Both osteoblastic and adipogenic differentiation in these progenitor populations was influenced by embryonic lineage and by genotype. Adipogenesis was enhanced in wild-type (WT) fNCSC compared to pMSC, but transgenic cultures showed strong suppression of lipid accumulation only in fNCSC cells. Osteoblastogenesis was significantly increased in transgenic fNCSC cultures compared to WT. Osteocalcin (OC) and ALP mRNA levels were also increased in fNCSC cultures from AR3.6-tg vs. WT, but in pMSC cultures ALP mRNA levels, mineralization and nodule formation were decreased in AR3.6-tg cells.

Внутри статьи:
- We next characterized osteogenic potential in neural crest vs. mesenchymal lineages and the effect of androgen on differentiation... Combined, these results suggest that enhanced androgen signaling has opposite effects on lipid accumulation and on bone formation in progenitors depending on their embryonic origin.
- Calvaria provide a unique resource for isolation of multipotent stem-like cells derived from distinct embryological origins, with frontal bones originating from ectodermal neural crest cells while parietal bones originate from mesoderm mesenchymal cells.

Исходя из этого, я бы предположил, что "embryonic lineage" указывает на зародышевый слой, от которого происходят клетки.

Еще внутри статьи:
- Although the developmental origin of adipocytes remains an area of debate, it is likely that there is a strong contribution from the neural crest at least in some fat depots.
- Androgen signaling differentially influences bone at the periosteal vs. enodcortical bone surface in long bone by stimulating or inhibiting bone formation respectively.

Судя по предпоследнему предложению, "developmental origin" тоже какое-то отношение к слоям имеет. Складывается впечатление, что это одно и то же.

Я перевожу не эту статью. В тексте, который перевожу, эта статья указана в качестве источника и просто сказано, что андрогены могут по-разному действовать на остеогенез в зависимости от "the embryonic lineage and developmental origin of the cell". Просто одно предложение.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167018/
lerethel
Russian Federation
Local time: 20:57
Russian translation:эмбриональное происхождение
Explanation:
имхо, это в целом можно выразить так в тексте, который переводится
Selected response from:

Igor Andreev
Local time: 20:57
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4Эмбриональная дифференцировка и происхождение клетки
Doctor Alex
3эмбриональное происхождение
Igor Andreev


  

Answers


10 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
эмбриональное происхождение


Explanation:
имхо, это в целом можно выразить так в тексте, который переводится


Igor Andreev
Local time: 20:57
Native speaker of: Native in RussianRussian
PRO pts in category: 806
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10 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
Эмбриональная дифференцировка и происхождение клетки


Explanation:
.


Doctor Alex
Local time: 20:57
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 698
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