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  3. Medical (general)

auszudosieren

English translation: (make a translator's note)

06:56 Apr 26, 2020
German to English translations [PRO]
Medical - Medical (general) / Medical report
German term or phrase: auszudosieren
In der Zusammenschau der heutigen Befunde zeigt sich ein leichtes PD-MCI, deswegen halte ich es für sinnvoll, Artane zunächst mal die Abenddosis auszudosieren und die Tagesdosis in der einer Folgewoche auf Morgens und Mittags 1 Tbl. zu reduzieren.
Eren Kutlu Carnì
Italy
Local time: 18:38
English translation:(make a translator's note)
Explanation:
If you asked me about the meaning of 'ausdosieren' without context, I would not hesitate to answer: ramp up the dose to the maximum tolerated dose.

1) Here, the context seems to point to the opposite – why should the evening dose be pushed to the maximum possible, when the morning and midday doses are subsequently reduced?
2) Based on all the errors, this author seems to use his language carelessly.
3) There is some evidence that 'ausdosieren' may be understood as increasing as well as decreasing the dose (see e.g. https://dict.leo.org/forum/viewUnsolvedquery.php?idForum=1&i... ).

This is a rather vague and nebulous basis for a translation, and as errors in both directions may cause serious consequences for the patient, my choice would be to offer both options and make a translator's note regarding the ambiguity.

--------------------------------------------------
Note added at 15 hrs (2020-04-26 22:17:11 GMT)
--------------------------------------------------



Re: increase the evening dose and decrease the daytime doses to reduce side effects during the day: I agree that there are drugs and situations where this concept works well (for example, with antihistamines for reducing daytime sleepiness). On the other hand, Artane is given in 3-4 divided doses and is therefore probably short-acting --> The patient would get no benefit from a high evening dose which improves his/her extrapyramidal movement disorder during the night. Neither is this strategy mentioned or recommended in the product information as a strategy for improving the performance of Artane.

That's why I feel the situation is too ambiguous to just go ahead and translate the usual meaning.
Selected response from:

Anne Schulz
Germany
Local time: 18:38
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +7(make a translator's note)
Anne Schulz
4 +2phase out the evening dose
Barbara Schmidt, M.A. (X)
3 +1gradually ramp up the dose
Michael Martin, MA
4incrementally increase the dose
tempusername
3down titrate
José Patrício


Discussion entries: 4





  

Answers


53 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
down titrate


Explanation:

https://www.dict.cc/?s=Ausdosierung
down titrate - decrease the dosage of the drug - https://www.proz.com/kudoz/english/medical-general/1694486-d...
Dose titration is the most important principle in opioid therapy. The dose should be gradually increased until favorable effects occur or intolerable and unmanageable side effects supervene. - https://www.sciencedirect.com/topics/medicine-and-dentistry/...

José Patrício
Portugal
Local time: 17:38
Native speaker of: Native in PortuguesePortuguese
PRO pts in category: 8

Peer comments on this answer (and responses from the answerer)
neutral  Michael Martin, MA: Your definitions contradict each other. The second one seems useful but not the first one.
4 hrs
  -> The second is only to understsnd the idea, not answer
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53 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
phase out the evening dose


Explanation:
my suggestion for you

--------------------------------------------------
Note added at 53 Min. (2020-04-26 07:50:42 GMT)
--------------------------------------------------

https://dictionary.cambridge.org/dictionary/english/phase-st...

Barbara Schmidt, M.A. (X)
Germany
Local time: 18:38
Specializes in field
Native speaker of: German
PRO pts in category: 119

Peer comments on this answer (and responses from the answerer)
agree  franglish
1 hr
agree  Ramey Rieger (X): Got my vote
1 hr
neutral  Michael Martin, MA: I think it's the other way around, Barbara.
4 hrs
agree  Lancashireman: In the sense of 'wean the patient off'. Borne out by 'reduzieren' in the subsequent clause.
5 hrs
disagree  tempusername: It's the opposite in this case; see Mr. Martin's and my answers, please.
1 day 7 hrs
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5 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
gradually ramp up the dose


Explanation:
I am going by this definition:
"in der Regel langsames Steigern der Dosis eines Medikaments bis zur Beschwerdefreiheit oder bis zum Auftreten von Nebenwirkungen; Verträglichkeitsgrenze"
https://www.epilepsie-gut-behandeln.de/service/epilepsie-lex...

Compare:
"2) Ramp up the dose of NDF™ until the patient is able to consume 2 ml (52 drops) at a time with no 'healing crisis' for at least 3 days." http://webcache.googleusercontent.com/search?q=cache:w4wzw1q...

--------------------------------------------------
Note added at 7 hrs (2020-04-26 14:19:52 GMT)
--------------------------------------------------

ausdosiert
Der Patient ist jetzt ausdosiert.

Gemeint ist: Man kann jetzt nicht mehr höher dosieren. https://books.google.com/books?id=2fAfBAAAQBAJ&pg=PA42&lpg=P...

Michael Martin, MA
United States
Local time: 12:38
Works in field
Native speaker of: Native in GermanGerman, Native in EnglishEnglish
PRO pts in category: 159

Peer comments on this answer (and responses from the answerer)
neutral  Lancashireman: Hope you have specialist medical insurance for death caused by mistranslation, Michael.
1 hr
  -> I'm in pretty good company here. Besides, there may be people out there who could use some kind of coverage just for general translation.
agree  metranslations: If they wanted to say "decrease", they would use a different word like ausschleichen. Ausdosieren means to gradually increase the dose. https://www.zentiva.de/service/glossar
5 hrs
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12 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +7
(make a translator's note)


Explanation:
If you asked me about the meaning of 'ausdosieren' without context, I would not hesitate to answer: ramp up the dose to the maximum tolerated dose.

1) Here, the context seems to point to the opposite – why should the evening dose be pushed to the maximum possible, when the morning and midday doses are subsequently reduced?
2) Based on all the errors, this author seems to use his language carelessly.
3) There is some evidence that 'ausdosieren' may be understood as increasing as well as decreasing the dose (see e.g. https://dict.leo.org/forum/viewUnsolvedquery.php?idForum=1&i... ).

This is a rather vague and nebulous basis for a translation, and as errors in both directions may cause serious consequences for the patient, my choice would be to offer both options and make a translator's note regarding the ambiguity.

--------------------------------------------------
Note added at 15 hrs (2020-04-26 22:17:11 GMT)
--------------------------------------------------



Re: increase the evening dose and decrease the daytime doses to reduce side effects during the day: I agree that there are drugs and situations where this concept works well (for example, with antihistamines for reducing daytime sleepiness). On the other hand, Artane is given in 3-4 divided doses and is therefore probably short-acting --> The patient would get no benefit from a high evening dose which improves his/her extrapyramidal movement disorder during the night. Neither is this strategy mentioned or recommended in the product information as a strategy for improving the performance of Artane.

That's why I feel the situation is too ambiguous to just go ahead and translate the usual meaning.

Anne Schulz
Germany
Local time: 18:38
Specializes in field
Native speaker of: German
PRO pts in category: 1611
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  metranslations: Definitely ask the author (if possible) or give both options. However, in some cases it does make sense to increase the evening dose, particularly if there are too many side effects that could be avoided during the day.
14 mins
  -> Danke Manuela :-)
agree  Veronika Neuhold: Here, it definitely makes sense to increase the evening dose. Nevertheless, the author should be consulted./Yes!!
1 hr
  -> Danke Veronika (und siehe added note)!
agree  Björn Vrooman: Too risky, IMO. This link uses ausdosieren as a synonym of ausschleichen: https://www.sigma-zentrum.de/pf/gaste-forum-fur-patienten/th... But this seems to support the opposite: https://europepmc.org/article/pmc/pmc3994190
1 hr
  -> Danke Björn!
agree  Lancashireman: Yes, as a translator you have to cover yourself. Imagine the ensuing lawsuit!
2 hrs
  -> OK... I'd rather say, imagine the poor patient coming from abroad and having a necessary treatment withdrawn or a toxic treatment escalated, based on the report he or she presented from the foreign doctor :-((
agree  Susanne Schiewe
16 hrs
  -> Danke Susanne :-)
agree  Michele Fauble
22 hrs
  -> Thank you Michele :-)
agree  Becca Resnik: Considering this much ambiguity, between opposite meanings no less, and the potential dire result, definitely better to get clarification.
1 day 1 hr
  -> Thank you Becca :-)
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1 day 8 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
incrementally increase the dose


Explanation:
I agree with Mr. Martin and Ms. Neuhold, though I would suggest wording it a bit more in accordance with traditional 'medical speech' as "incrementally increase the dose". But, yes, it means to ramp up the dose, essentially. This is the incremental increasing of a dose for cautious monitoring of any side effects and to determine the threshold amount at which symptoms abate.

Example sentence(s):
  • This approach provides the patient with some personal control over analgesic dosing and can be used to estimate the increment in the fixed dose.
  • It is wise to initiate levothyroxine therapy with smaller doses such as 25–50 μg levothyroxine and incrementally increase the dose to full replacement to avoid precipitating cardiac ischaemia.

    https://www.epilepsie-gut-behandeln.de/service/epilepsie-lexikon/detail/649/ausdosieren-ausdosierung
tempusername
Local time: 12:38
Specializes in field
Native speaker of: Native in EnglishEnglish
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