pre-shoulder

Spanish translation: antes de/anterior a la cresta de los picos

19:08 Feb 6, 2020
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / pre-shoulder
English term or phrase: pre-shoulder
Figure 1:
Chromatogram of xxx (nombre del medicamento) working reference standard xxx, 1 mg/ml.
Integration range of IPC-samples and DS release samples within IPC sequences (examples for HPLC lines):
Integration of IPC samples is performed within an integration window of about 4 to 23 min and a UV-signal range from -20 mAU to +50 mAU (zoomed range from -10 mAU to +5 or +10 mAU, if required for integration of very small peaks, a higher zoom factor can be applied).
For identification of low intensity signals and developing shoulders it is recommended to perform overlays with reference chromatograms.
For a consistent integration the splitting of the pre-shoulder of xxx (nombre del medicamento) for IPC samples (e.g. RPC fractions) is performed with defined zoom window.

Muchas gracias.
Romina Zaleski
Local time: 22:37
Spanish translation:antes de/anterior a la cresta de los picos
Explanation:
Creo que se refiere a esto:

http://www.lcresources.com/resources/TSWiz/hs60.htm
4. Peaks with shoulders
There is no specific measurement for the degree of a "shoulder" on a peak. In most cases, the presence of a significant shoulder will increase the measured tailing factor and/or decrease the measured plate count. Characterization as a shoulder, however, is a subjective judgment on the part of the chromatographer.

https://www.silicycle.com/faq/hplc/why-is-my-chromatogram-sh...

Peak splitting or double peaks is usually symptomatic of a void at column inlet, a partially blocked inlet frit (not necessarily leading to a pressure increase) and anything else that causes a disruption of the sample path where the sample follows multiple paths throughout the column. This phenomenon also occurs when the column is poorly packed and that the packing bed settles under the system pressure or that the mobile phase pH is too high and dissolves the silica thus creating a void at the column inlet.

If all the peaks in the chromatogram have shoulders and the problem has gradually been getting worse, then a void at the column head has to be considered as a strong possibility. Not much can be done to save the column and you are better off replacing the column.

En caso de estar en lo cierto:
"shoulder" sería la cresta de los picos y "pre-shoulder" sería "antes de/anterior a la cresta de los picos".

https://www.studocu.com/es/document/universidad-pablo-de-ola...

http://grados.ugr.es/telecomunicacion/pages/evidencias2015/t...


¡Mucha suerte!
Selected response from:

Sandra García Alonso
Spain
Local time: 03:37
Grading comment
Muchas gracias por la ayuda.
4 KudoZ points were awarded for this answer



Summary of answers provided
4zona previa al hombro
José Miguel Lasarte
3antes de/anterior a la cresta de los picos
Sandra García Alonso
3hombro frontal (pre-hombro)
Chema Nieto Castañón


Discussion entries: 3





  

Answers


19 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
antes de/anterior a la cresta de los picos


Explanation:
Creo que se refiere a esto:

http://www.lcresources.com/resources/TSWiz/hs60.htm
4. Peaks with shoulders
There is no specific measurement for the degree of a "shoulder" on a peak. In most cases, the presence of a significant shoulder will increase the measured tailing factor and/or decrease the measured plate count. Characterization as a shoulder, however, is a subjective judgment on the part of the chromatographer.

https://www.silicycle.com/faq/hplc/why-is-my-chromatogram-sh...

Peak splitting or double peaks is usually symptomatic of a void at column inlet, a partially blocked inlet frit (not necessarily leading to a pressure increase) and anything else that causes a disruption of the sample path where the sample follows multiple paths throughout the column. This phenomenon also occurs when the column is poorly packed and that the packing bed settles under the system pressure or that the mobile phase pH is too high and dissolves the silica thus creating a void at the column inlet.

If all the peaks in the chromatogram have shoulders and the problem has gradually been getting worse, then a void at the column head has to be considered as a strong possibility. Not much can be done to save the column and you are better off replacing the column.

En caso de estar en lo cierto:
"shoulder" sería la cresta de los picos y "pre-shoulder" sería "antes de/anterior a la cresta de los picos".

https://www.studocu.com/es/document/universidad-pablo-de-ola...

http://grados.ugr.es/telecomunicacion/pages/evidencias2015/t...


¡Mucha suerte!


    Reference: http://www.lcresources.com/resources/TSWiz/hs60.htm
Sandra García Alonso
Spain
Local time: 03:37
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 16
Grading comment
Muchas gracias por la ayuda.
Login to enter a peer comment (or grade)

1 day 17 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
hombro frontal (pre-hombro)


Explanation:
Posiblemente aluda a un hombro frontal (versus hombro trasero), esto es, un hombro previo al pico principal. Sólo he encontrado un ejemplo equivalente en castellano como pre-hombro;

Ambos picos no fueron simétricos y presentaban un pre-hombro.
https://www.google.com/url?sa=t&source=web&rct=j&url=http://...

Hombro
https://m.monografias.com/trabajos46/separacion-bandas/separ...

Hombro (frontal, trasero)
Se producen hombros cuando dos picos eluyen tan cerca el uno del otro que no llega a haber un valle entre ellos que permita resolverlos. Los hombros pueden aparecer en el avance del pico (hombro frontal) o en el rastro del mismo (hombro trasero). Cuando se detectan hombros, éstos pueden integrarse bien mediante división tangencial o mediante líneas de caída verticales.
https://www.google.com/url?sa=t&source=web&rct=j&url=https:/...


Chema Nieto Castañón
Spain
Local time: 03:37
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 553
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7 days   confidence: Answerer confidence 4/5Answerer confidence 4/5
zona previa al hombro


Explanation:
Entiendo que hombro es el punto de inflexión que se observa en un cromatograma cuando dos picos no están bien separados y que, por tanto, pre-shoulder<i/> debe ser la zona inmediatamente anterior a dicho punto de inflexión.

José Miguel Lasarte
Spain
Local time: 02:37
Works in field
Native speaker of: Spanish
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