Wirkfluktuation

English translation: motor fluctuations (connected with gaps in medication effectiveness)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:Wirkfluktuation
English translation:motor fluctuations (connected with gaps in medication effectiveness)
Entered by: Stuart and Aida Nelson

05:48 Jun 1, 2019
German to English translations [PRO]
Medical - Medical (general)
German term or phrase: Wirkfluktuation
M. Parkinson vom akinetisch-rigiden Typ rechtsbetont mit ***Wirkfluktuation*** und Hyperkinesen

What is the appropriate term in English? Any suggestions?
Sonja Poeltl
Local time: 01:21
motor fluctuations (connected with gaps in medication effectiveness)
Explanation:

I don't know if there is a standard term in English for Wirkfluktuation. I couldn't find any references to fluctuations of medication effectiveness but quite a lot about motor fluctuations.

Medication often loses its effectiveness with progression of the disease which causes motor fluctuations.

At this point, motor fluctuations (also called “on-off” fluctuations) may begin to appear.

They are designed to take effect quickly: within 15 minutes or less. Typically, the response is short, maybe an hour or two. It is called “rescue” therapy because it bridges gaps in other medication effectiveness.

Although at this time there is no way to correct the brain changes that cause Parkinson’s, we know that exercise can help you maintain your ability chapter one About Parkinson’s Disease 5 to fight the disease and that staying healthy can reduce setbacks that make PD progress faster.
https://parkinson.org/sites/default/files/attachments/MidStr...

Fluctuations in performance in patients with Parkinson's disease on chronic levodopa therapy (the "on-off" effect) are due to several factors. The increasing severity during treatment of early morning akinesia, "freezing" episodes, and end-of-dose deterioration are probably due to progression of the underlying disease. Peak-dose dyskinesia and peak-dose akinesia are due to levodopa over-dosage. "Yo-yo-ing", which is the severest form of such fluctuation in mobility and dyskinesias, may represent the sum of these disorders.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Die Behandlung mit Medikamenten ist bei Parkinson-Patienten ein wesentlicher Bestandteil der Therapie. Individuell auf den Patienten und seine Beschwerden abgestimmt, können Parkinson-Medikamente die Krankheitssymptome lange Zeit deutlich verbessern. Mit zunehmender Krankheitsdauer kann jedoch die Wirksamkeit der Medikamente nachlassen, und es können sogenannte Spätkomplikationen auftreten. Dies gilt vor allem für Arzneimittel, die den fehlenden Botenstoff Dopamin im Gehirn ersetzen sollen (L-Dopa, dopaminerge Medikamente).
https://www.parkinson-aktuell.de/was-ist-parkinson/parkinson...

Befragt zur Medikation gab ein Drittel an, fünf oder mehr Medikamente täglich zu benötigen, 30 Prozent mussten fünfmal täglich ein Medikament einnehmen, so Wüllner auf dem Parkinsonkongress in Ulm. Auf die Frage, was bei der Therapie verbessert werden sollte, gaben 53 Prozent an, dass sie sich eine Therapie wünschen, die Wirkungsfluktuationen stärker lindert, also plötzlich auftretende Phasen schlechter Beweglichkeit reduziert
https://www.aerztezeitung.de/medizin/krankheiten/neuro-psych...
Selected response from:

Stuart and Aida Nelson
United Kingdom
Local time: 05:21
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2motor fluctuations (connected with gaps in medication effectiveness)
Stuart and Aida Nelson
5fluctuation
Cillie Swart
3fluctuations of the (therapeutic) effect/ changes in effectiveness
Ebrahim Mohammed
2fluctuating presence/activity
Ramey Rieger (X)


  

Answers


2 hrs   confidence: Answerer confidence 2/5Answerer confidence 2/5
fluctuating presence/activity


Explanation:
Perhaps

Ramey Rieger (X)
Germany
Local time: 06:21
Native speaker of: English
PRO pts in category: 95
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6 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
motor fluctuations (connected with gaps in medication effectiveness)


Explanation:

I don't know if there is a standard term in English for Wirkfluktuation. I couldn't find any references to fluctuations of medication effectiveness but quite a lot about motor fluctuations.

Medication often loses its effectiveness with progression of the disease which causes motor fluctuations.

At this point, motor fluctuations (also called “on-off” fluctuations) may begin to appear.

They are designed to take effect quickly: within 15 minutes or less. Typically, the response is short, maybe an hour or two. It is called “rescue” therapy because it bridges gaps in other medication effectiveness.

Although at this time there is no way to correct the brain changes that cause Parkinson’s, we know that exercise can help you maintain your ability chapter one About Parkinson’s Disease 5 to fight the disease and that staying healthy can reduce setbacks that make PD progress faster.
https://parkinson.org/sites/default/files/attachments/MidStr...

Fluctuations in performance in patients with Parkinson's disease on chronic levodopa therapy (the "on-off" effect) are due to several factors. The increasing severity during treatment of early morning akinesia, "freezing" episodes, and end-of-dose deterioration are probably due to progression of the underlying disease. Peak-dose dyskinesia and peak-dose akinesia are due to levodopa over-dosage. "Yo-yo-ing", which is the severest form of such fluctuation in mobility and dyskinesias, may represent the sum of these disorders.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Die Behandlung mit Medikamenten ist bei Parkinson-Patienten ein wesentlicher Bestandteil der Therapie. Individuell auf den Patienten und seine Beschwerden abgestimmt, können Parkinson-Medikamente die Krankheitssymptome lange Zeit deutlich verbessern. Mit zunehmender Krankheitsdauer kann jedoch die Wirksamkeit der Medikamente nachlassen, und es können sogenannte Spätkomplikationen auftreten. Dies gilt vor allem für Arzneimittel, die den fehlenden Botenstoff Dopamin im Gehirn ersetzen sollen (L-Dopa, dopaminerge Medikamente).
https://www.parkinson-aktuell.de/was-ist-parkinson/parkinson...

Befragt zur Medikation gab ein Drittel an, fünf oder mehr Medikamente täglich zu benötigen, 30 Prozent mussten fünfmal täglich ein Medikament einnehmen, so Wüllner auf dem Parkinsonkongress in Ulm. Auf die Frage, was bei der Therapie verbessert werden sollte, gaben 53 Prozent an, dass sie sich eine Therapie wünschen, die Wirkungsfluktuationen stärker lindert, also plötzlich auftretende Phasen schlechter Beweglichkeit reduziert
https://www.aerztezeitung.de/medizin/krankheiten/neuro-psych...


Stuart and Aida Nelson
United Kingdom
Local time: 05:21
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish
PRO pts in category: 31
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  Johanna Timm, PhD: on-off phenomenon
14 hrs
  -> Thank, you, Johanna, much appreciated, greetings from Merseyside, UK :)

agree  Anne Schulz: Merseyside ... "You never see the sea at Southport" – sigh! // My landlord used to quote that as a common saying when I stayed in Southport :-)
1 day 12 hrs
  -> Thank you, Anne, yes, you are right the sea is far away many times in Southport, what a shame, greetings from sunny Merseyside :)
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6 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
fluctuations of the (therapeutic) effect/ changes in effectiveness


Explanation:

fluctuations of the (therapeutic) effect

changes in effectiveness

effective fluctuation

Ebrahim Mohammed
Germany
Local time: 06:21
Specializes in field
Native speaker of: Native in ArabicArabic
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5 days   confidence: Answerer confidence 5/5
fluctuation


Explanation:
Fluctuation alone in this context. The rest of the text gives away the meaning.


    Reference: http://www.linguee.com
Cillie Swart
South Africa
Local time: 07:21
Native speaker of: Native in EnglishEnglish
PRO pts in category: 62
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