GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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14:31 May 30, 2019 |
Spanish to English translations [PRO] Medical - Medical (general) | |||||||
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| Selected response from: Charles Davis Spain Local time: 19:43 | ||||||
Grading comment
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moderate peritumoral and intratumoral inflammatory infiltrate consisting of lymphocytes Explanation: The stroma showed moderate inflammatory infiltrate consisting of lymphocytes and plasma cells https://www.omicsonline.org/open-access/oral-inflammatory-my... In order to quantify the peritumoral inflammatory infiltrate, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556313/ Tumor-infiltrating lymphocytes (TILs) have prognostic significance in breast cancer. ... the presence of peritumoral lymphocytic infiltration, moderate to .... and score 3, florid cup-like inflammatory infiltrate https://academic.oup.com/ajcp/article/144/2/278/1766794 There were no such associations of lymphocyte infiltration in the tumor. A high density of CD20+ peritumoral lymphocytes is an independent .. https://bmcclinpathol.biomedcentral.com/articles/10.1186/147... Histologic evaluation of control and treatment samples also supported a stronger peritumoral and intratumoral inflammatory infiltrate in treated samples (Fig. 5). https://www.researchgate.net/figure/Representative-example-o... |
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moderate peri-and intratumoral lymphocytic (and plasma cell) infiltrate Explanation: "A moderate amount of peri- and intratumoral lymphocytic infiltrate was seen on hematoxylin-eosin (H&E) stain and CD8 immunostain." "Moderate peri-and intratumoral lymphocytic infiltrate is highlighted by CD8 immunostain." From an article by a group at Yale University School of Medicine. Clin Cancer Res . 2016 December 1; 22(23): 5682–5687 https://www.researchgate.net/publication/305803426_Regressio... "The large majority (94%) of ductal tumours had evidence of inflammatory cell infiltrate. [...] On univariate analysis, stratified for ER status, tumour size (P<0.01), lymph node involvement (P<0.001), tumour plasma cell infiltrate (P<0.001), other inflammatory cell infiltrate (P<0.05) and treatment (P<0.05) were associated with poorer cancer-specific survival" Mohammed ZM, Going JJ, Edwards J, Elsberger B, Doughty JC, McMillan DC. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Br J Cancer. 2012 Aug 21;107(5):864-73 https://www.ncbi.nlm.nih.gov/pubmed/22878371 -------------------------------------------------- Note added at 35 mins (2019-05-30 15:07:21 GMT) -------------------------------------------------- Sorry, I missed out "inflamatorio". It should be: moderate inflammatory peri-and intratumoral lymphocytic infiltrate -------------------------------------------------- Note added at 40 mins (2019-05-30 15:11:49 GMT) -------------------------------------------------- Or moderate peri- and intratumoral inflammatory lymphocytic infiltrate if you prefer. "at dermo-hypodermal level we can observe moderate inflammatory lymphocytic infiltrate" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876001/ |
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