Infiltrado inflamatorio moderado peri e intratumoral por linfocitos

English translation: moderate peri-and intratumoral inflammatory lymphocytic (and plasma cell) infiltrate

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:Infiltrado inflamatorio moderado peri e intratumoral por linfocitos
English translation:moderate peri-and intratumoral inflammatory lymphocytic (and plasma cell) infiltrate
Entered by: Charles Davis

14:31 May 30, 2019
Spanish to English translations [PRO]
Medical - Medical (general)
Spanish term or phrase: Infiltrado inflamatorio moderado peri e intratumoral por linfocitos
Hola, estoy traduciendo un informe anatomopatológico sobre cáncer de mama. En la descripción microscópica dice:

"En el estroma se observa desmoplasia moderada y degeneración mixoide e infiltrado inflamatorio moderado peri e intratumoral por linforcitos y células plasmáticas"

¿Alguna sugerencia?

Gracias de antemano!!
Natalí Felcaro
Argentina
Local time: 15:43
moderate peri-and intratumoral lymphocytic (and plasma cell) infiltrate
Explanation:
"A moderate amount of peri- and intratumoral lymphocytic infiltrate was seen on hematoxylin-eosin (H&E) stain and CD8 immunostain."
"Moderate peri-and intratumoral lymphocytic infiltrate is highlighted by CD8 immunostain."
From an article by a group at Yale University School of Medicine. Clin Cancer Res
. 2016 December 1; 22(23): 5682–5687
https://www.researchgate.net/publication/305803426_Regressio...

"The large majority (94%) of ductal tumours had evidence of inflammatory cell infiltrate. [...] On univariate analysis, stratified for ER status, tumour size (P<0.01), lymph node involvement (P<0.001), tumour plasma cell infiltrate (P<0.001), other inflammatory cell infiltrate (P<0.05) and treatment (P<0.05) were associated with poorer cancer-specific survival"
Mohammed ZM, Going JJ, Edwards J, Elsberger B, Doughty JC, McMillan DC. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Br J Cancer. 2012 Aug 21;107(5):864-73
https://www.ncbi.nlm.nih.gov/pubmed/22878371


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Note added at 35 mins (2019-05-30 15:07:21 GMT)
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Sorry, I missed out "inflamatorio". It should be:

moderate inflammatory peri-and intratumoral lymphocytic infiltrate


--------------------------------------------------
Note added at 40 mins (2019-05-30 15:11:49 GMT)
--------------------------------------------------

Or moderate peri- and intratumoral inflammatory lymphocytic infiltrate if you prefer.

"at dermo-hypodermal level we can observe moderate inflammatory lymphocytic infiltrate"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876001/
Selected response from:

Charles Davis
Spain
Local time: 19:43
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +4moderate peri-and intratumoral lymphocytic (and plasma cell) infiltrate
Charles Davis
4moderate peritumoral and intratumoral inflammatory infiltrate consisting of lymphocytes
Stuart and Aida Nelson


  

Answers


33 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
moderate peritumoral and intratumoral inflammatory infiltrate consisting of lymphocytes


Explanation:

The stroma showed moderate inflammatory infiltrate consisting of lymphocytes and plasma cells
https://www.omicsonline.org/open-access/oral-inflammatory-my...

In order to quantify the peritumoral inflammatory infiltrate,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556313/

Tumor-infiltrating lymphocytes (TILs) have prognostic significance in breast cancer. ... the presence of peritumoral lymphocytic infiltration, moderate to .... and score 3, florid cup-like inflammatory infiltrate
https://academic.oup.com/ajcp/article/144/2/278/1766794

There were no such associations of lymphocyte infiltration in the tumor. A high density of CD20+ peritumoral lymphocytes is an independent ..
https://bmcclinpathol.biomedcentral.com/articles/10.1186/147...

Histologic evaluation of control and treatment samples also supported a stronger peritumoral and intratumoral inflammatory infiltrate in treated samples (Fig. 5).
https://www.researchgate.net/figure/Representative-example-o...


Stuart and Aida Nelson
United Kingdom
Local time: 18:43
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish
PRO pts in category: 103
Login to enter a peer comment (or grade)

31 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +4
moderate peri-and intratumoral lymphocytic (and plasma cell) infiltrate


Explanation:
"A moderate amount of peri- and intratumoral lymphocytic infiltrate was seen on hematoxylin-eosin (H&E) stain and CD8 immunostain."
"Moderate peri-and intratumoral lymphocytic infiltrate is highlighted by CD8 immunostain."
From an article by a group at Yale University School of Medicine. Clin Cancer Res
. 2016 December 1; 22(23): 5682–5687
https://www.researchgate.net/publication/305803426_Regressio...

"The large majority (94%) of ductal tumours had evidence of inflammatory cell infiltrate. [...] On univariate analysis, stratified for ER status, tumour size (P<0.01), lymph node involvement (P<0.001), tumour plasma cell infiltrate (P<0.001), other inflammatory cell infiltrate (P<0.05) and treatment (P<0.05) were associated with poorer cancer-specific survival"
Mohammed ZM, Going JJ, Edwards J, Elsberger B, Doughty JC, McMillan DC. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Br J Cancer. 2012 Aug 21;107(5):864-73
https://www.ncbi.nlm.nih.gov/pubmed/22878371


--------------------------------------------------
Note added at 35 mins (2019-05-30 15:07:21 GMT)
--------------------------------------------------

Sorry, I missed out "inflamatorio". It should be:

moderate inflammatory peri-and intratumoral lymphocytic infiltrate


--------------------------------------------------
Note added at 40 mins (2019-05-30 15:11:49 GMT)
--------------------------------------------------

Or moderate peri- and intratumoral inflammatory lymphocytic infiltrate if you prefer.

"at dermo-hypodermal level we can observe moderate inflammatory lymphocytic infiltrate"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876001/

Charles Davis
Spain
Local time: 19:43
Native speaker of: English
PRO pts in category: 804

Peer comments on this answer (and responses from the answerer)
agree  raptisi
23 mins
  -> Many thanks, raptisi :-)

agree  Chema Nieto Castañón
27 mins
  -> Many thanks, Chema ;-)

agree  María Patricia Arce: also lymphoplasmacytic infiltrate
1 hr
  -> You're right! Thanks very much, María Patricia :-)

agree  JohnMcDove
2 hrs
  -> Muchas gracias, John ;-) ¡Menudo trabalenguas!
Login to enter a peer comment (or grade)



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