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в линиях клеток-предшественников Т-клеточного происхождения

English translation: in the blood-cell lineages derived from T-cell progenitors

23:19 Feb 12, 2019
Russian to English translations [PRO]
Medical - Medical: Pharmaceuticals
Russian term or phrase: в линиях клеток-предшественников Т-клеточного происхождения
Ara-GTP является «ложным» нуклеотидом и как таковой он предотвращает репликацию ДНК путем блокирования присоединения других дезоксинуклеотидов к цепи, приводящему к ингибированию синтеза ДНК, к фрагментации молекулы ДНК с большой молекулярной массой и к гибели клеток [26].
Ara-GTP, в отличие от других аналогов нуклеозидов, достигает концентраций в линиях клеток-предшественников Т-клеточного происхождения в 20-40 раз выше, чем таковые в В-лимфоцитах [30], и поэтому его применение в первую очередь приводит к гибели Т-клеток [25, 29].
Более высокая концентрация ara-GTP в Т-лимфоцитах по всей видимости определяет Т-клеточную селективную токсичность, однако другие факторы также могут иметь значение, например, резистентность не-Т-клеточных лимфоцитов к ara-G и активация FAS-опосредованного пути индукции апоптоза в Т-, но не В-лимфоцитах [25, 29].
Anastasia Serdyukova
Russian Federation
Local time: 04:23
English translation:in the blood-cell lineages derived from T-cell progenitors
Explanation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972740/

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ar.a.10133

https://www.sciencedirect.com/science/article/pii/S107476130...
Selected response from:

svetlana cosquéric
France
Local time: 03:23
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +1in the blood-cell lineages derived from T-cell progenitors
svetlana cosquéric
3in T-cell precursor cell lines
Vladyslav Golovaty


  

Answers


27 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
in T-cell precursor cell lines


Explanation:

B-cell Precursor Cell Lines https://www.researchgate.net/publication/302564462_B-cell_Pr...


Vladyslav Golovaty
Ukraine
Local time: 04:23
Works in field
Native speaker of: Native in EnglishEnglish, Native in RussianRussian
PRO pts in category: 158
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11 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
in the blood-cell lineages derived from T-cell progenitors


Explanation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972740/

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ar.a.10133

https://www.sciencedirect.com/science/article/pii/S107476130...

svetlana cosquéric
France
Local time: 03:23
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 60

Peer comments on this answer (and responses from the answerer)
agree  Natalie
9 hrs
  -> Спасибо, Натали!
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