cross-over double head

05:44 Aug 4, 2016
English to Italian translations [PRO]
Law/Patents - Biology (-tech,-chem,micro-) / brevetto anticorpi
English term or phrase: cross-over double head
anticorpi a doppia testa crociata? non trovo riscontri...grazie

The second configuration of a bispecific antibody fragment described in U.S. Patent No. 5,989,830 is the cross-over double head (CODH), having the following orientation of variable domains expressed on two chains:

In the cross-over double head configuration, the variable domains of two different antibodies are expressed in a tandem orientation on two separate polypeptide chains

Computer modeling predicted that the cross-over double-head (CODH) design of U.S. Patent No. 5,989,830 would yield a complex in which both binding sites face in the opposite direction, without the restraints suggested for the Dual-Fv configuration of U.S. Patent No. 7,612,181.
daria fedele
Italy
Local time: 19:09



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