17:36 Jul 8, 2014
Oi, Samantha e colegas, desculpe não ter colocado mais contexto. Falha minha! Aqui vai: The primary mode of action of organophosphates is to inhibit neuronal acetylcholinesterase (AChE). This leads to excessive acetylcholine at sympathetic, parasympathetic, CNS, and neuromuscular junction sites. Parasympathetic effects are predominant early on in most poisonings, causing excessive secretions, bronchospasm, diarrhoea, and pinpoint pupils. Sympathetic effects may lead to hypertension and tachycardia. CNS cholinergic effects are important in severe poisonings, as they contribute to seizures and respiratory failure. Neuromuscular junction stimulation leads to early fasciculations and may lead to weakness that persists for days to weeks beyond the other features. Delayed-onset CNS and peripheral (predominantly motor) neuropathy are uncommon, but may be severe and can lead to permanent disability. |