up-/and down-regulation

Czech translation: zvýšení/snížení produkce

00:34 Jan 24, 2014
English to Czech translations [PRO]
Medical - Genetics
English term or phrase: up-/and down-regulation
In addition, genetic analyses with regard to the up-/and down-regulation of the production of biological marker molecules indication the efficacy of XY could be performed from additional x tissue samples (biopsies) taken each during endoscopy at screening...
Jirina Nevosadova
Czech Republic
Local time: 11:45
Czech translation:zvýšení/snížení produkce
Explanation:
Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.

An example of downregulation is the cellular decrease in the number of receptors to a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule.

An example of upregulation is the increased number of cytochrome P450 enzymes in liver cells when xenobiotic molecules such as dioxin are administered (resulting in greater degradation of these molecules).
http://en.wikipedia.org/wiki/Downregulation_and_upregulation

Selected response from:

Jan Ramza
Slovakia
Local time: 11:45
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1zvýšení/snížení produkce
Jan Ramza
4 +1up a down regulace / regulace (produkce) směrem nahoru a dolů
Ivan Šimerka
4regulace "před a za"
Kostas Zgafas


  

Answers


33 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
regulace "před a za"


Explanation:
...týkající se regulace "před a za"...

Bez hlubokého pochopení kontextu bych to asi takto "přechytračil"
S největší pravděpodobností to znamená "před" a "za" místem příslušného procesu

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Note added at 2 hrs (2014-01-24 02:35:14 GMT)
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...týkající se regulace "před a za" (čím)...

Kostas Zgafas
Czech Republic
Local time: 11:45
Works in field
Native speaker of: Native in CzechCzech
Login to enter a peer comment (or grade)

6 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
zvýšení/snížení produkce


Explanation:
Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.

An example of downregulation is the cellular decrease in the number of receptors to a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule.

An example of upregulation is the increased number of cytochrome P450 enzymes in liver cells when xenobiotic molecules such as dioxin are administered (resulting in greater degradation of these molecules).
http://en.wikipedia.org/wiki/Downregulation_and_upregulation



Jan Ramza
Slovakia
Local time: 11:45
Specializes in field
Native speaker of: Native in SlovakSlovak
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
agree  Václav Pinkava
7 hrs
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7 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
up a down regulace / regulace (produkce) směrem nahoru a dolů


Explanation:
viz


    Reference: http://lekarske.slovniky.cz/pojem/down-regulace
    Reference: http://lekarske.slovniky.cz/pojem/up-regulace
Ivan Šimerka
Czech Republic
Local time: 11:45
Native speaker of: Native in CzechCzech

Peer comments on this answer (and responses from the answerer)
agree  Ondrej Pisa: souhlas, up-regulace/down-regulace
1 hr
  -> já tedy dávám přednost plně české verzi, i když je delší
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