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  3. Medical: Pharmaceuticals

elevated signal

13:14 Sep 11, 2013
This question was closed without grading. Reason: Answer found elsewhere

English language (monolingual) [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: elevated signal
The United States Food and Drug Administration and European Medicines Agency advise against using EFV in the first trimester and in women of childbearing potential unless the potential benefits outweigh the potential risks; however, the British HIV Association recently changed its recommendation to allow EFV to be used in the first trimester (143). Because the risk of neural tube defects is limited to the first five to six weeks of pregnancy and because pregnancy is rarely recognized this early, especially in resource-limited settings, any potential risk of neural tube defects with the use of EFV would be primarily in women who become pregnant while already receiving EFV. Evaluation of prospectively collected data in humans is reassuring ; an updated systematic review and meta-analysis, including the Antiretroviral Pregnancy Registry (47,134), reported outcomes for 1502 live births to women receiving EFV in the first trimester and found no increase in overall birth defects and no elevated signal for EFV compared with other ARV exposure in pregnancy (140). With one identified neural tube defect, the estimated prevalence from the systematic review continues to be about 7 per 10 000 population (0.07%), which is comparable to the estimates of 0.02–0.2% in the general population in the USA (138).

http://www.who.int/hiv/pub/guidelines/arv2013/art/artpregnan...

Thank you for your help!
Nadia Ayoub
Egypt
Local time: 00:04


SUMMARY OF ALL EXPLANATIONS PROVIDED
4higher concentration
Piyush Ojha
3strong indicator
NancyLynn


Discussion entries: 2





  

Answers


7 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
strong indicator


Explanation:
-

NancyLynn
Canada
Local time: 18:04
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4
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57 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
higher concentration


Explanation:
The concentration (amount) of EFV (in the newborn?) was no greater than the concentration of other anti-retroviral agents in cases where an alternative was used.

Piyush Ojha
United Kingdom
Local time: 23:04
Native speaker of: Native in EnglishEnglish, Native in HindiHindi
PRO pts in category: 3
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