Mises au point techniques

English translation: technical details (have to be sorted out/ need to be fine-tuned)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

French term or phrase:	Mises au point techniques
English translation:	technical details (have to be sorted out/ need to be fine-tuned)
Entered by:	claude-andrew

08:25 Oct 27, 2012

French to English translations [PRO]
Medical - Medical: Pharmaceuticals / Pharmaceutical manufacturing performance qualification

French term or phrase: Mises au point techniques

That tricky "mise au point again". There are several sections under the section title - I give a representative selection. The Kudoz entry "Technical adjustments" isn't suitable, nor are any of the translations on Linguee or GDT.
A point to consider is: does "Certaines mises au point doivent être faites" mean "a certain number of things need to be pointed out", thus referring, not to the operations themselves but to the stating of those operations in the following sub-headings, or does it mean the actual operations?
In the latter case, the translation of "mises au point techniques" has to cover all of the points described.
In the former case, I simply need to use a suitably literate version of "a certain number of things need to be pointed out".

Pré requis techniques à la validation

Certaines **mises au point techniques** doivent être faites avant le démarrage d’une étude par le / la technicien(ne) physico chimie en charge des essais.

2.3.1 **Mise au point** de la méthode de traitement des échantillons

Cette méthode est utilisée pour traiter les prélèvements de validation et les essais nécessaires à la détermination des pré-requis analytiques.

Pour les prélèvements de surface, le / la technicien(ne) physico chimie doit déterminer :
 la quantité de solvant de récupération nécessaire ;
 les paramètres d’agitation (matériel employé, durée et vitesse) ;
 les paramètres de chauffage si besoin (matériel, durée, température).

Pour que la méthode de traitement des échantillons soit jugée acceptable, il faut qu’elle permette l’obtention d’un rendement d’extraction supérieur à 95 %.
Si le rendement d’extraction est inférieur à 95 %, modifier certains paramètres (quantité de solvant de récupération, vitesse et/ou durée d’agitation…) et redéterminer ce rendement.

Pour les eaux de rinçage, il faut définir par exemple si une dilution est nécessaire avant analyse.

2.3.2 Détermination du seuil de détection et du seuil de quantification

Les seuils de détection et de quantification sont déterminés selon la méthode décrite dans la Pharmacopée Européenne.

2.3.2.1 Seuil de détection :
Le seuil de détection est la concentration minimale de contaminant détectée par la méthode analytique retenue.
Ce seuil est déterminé à l’aide de la formule suivante :
SD = 3 = HD/h d’où HD = 3h
(etc.)

claude-andrew KudoZ activity Questions: 643 (9 open) (36 without valid answers) (70 closed without grading) Answers: 358 France
Local time: 10:24

technical details (have to be sorted out/ need to be fine-tuned)

Explanation:
I think that something not too far removed from the standard meaning would be fine. I know what you mean : "mettre au point" does not necessarily mean physically adjusting technical elements, but sorting out by explanation etc.

Perhaps something along the lines of the suggestions I have made might work for either/or, physical adjustments or sorting out technical details.

Selected response from:

Nikki Scott-Despaigne
Local time: 10:24

Grading comment

Thanks Nikki
4 KudoZ points were awarded for this answer

Summary of answers provided

3 +3

technical details (have to be sorted out/ need to be fine-tuned)

Nikki Scott-Despaigne

4 +1

adjustments

Bashiqa

...a number of parameters need to be determined...

EvaVer (X)

technical regulation and development

Tohid Sharifi

Preparation or set up

Valérie Lopez

3 +1

Aspects

kashew

Technical development

liz askew

Summary of reference entries provided

ICH guidelines

Leslie D

Discussion entries: 2

Answers

48 mins confidence:

peer agreement (net): +1

adjustments

Explanation:
Covers a multitude of 'mises au point'.

Bashiqa
France
Local time: 10:24
Specializes in field
Native speaker of:

English
PRO pts in category: 74

56 mins confidence:

...a number of parameters need to be determined...

Explanation:
c'est ce qu'ils veulent dire, l'expression "mise au point" est mal utilisée ici je pense

EvaVer (X)
Local time: 10:24
Works in field
Native speaker of:

Czech,

French
PRO pts in category: 11

1 hr confidence:

technical regulation and development

Explanation:
.

Tohid Sharifi
Cote D'ivoire
Local time: 08:24
Native speaker of:

Persian (Farsi)

1 hr confidence:

Preparation or set up

Explanation:
because this is like prior to the actual task, having everything ready to carry out the task

Certaines **mises au point techniques** doivent être faites avant le démarrage d’une étude par le / la technicien(ne) physico chimie en charge des essais.
there are a few preparation steps to be run before the study can start

2.3.1 **Mise au point** de la méthode de traitement des échantillons

Set up je pense que ça va bien ici

hope this helps

Valérie Lopez
Switzerland
Local time: 10:24
Native speaker of:

French

1 hr confidence:

peer agreement (net): +1

Aspects

Explanation:
*

kashew
France
Local time: 10:24
Native speaker of:

English
PRO pts in category: 7

1 hr confidence:

Technical development

Explanation:
http://www.coe.int/newssearch/Default.asp?p=nwz&id=18&lmLang...

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Note added at 1 hr (2012-10-27 10:08:09 GMT)
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or
technological

Committee of Ministers - Council of Europe Information Policy ...
https://wcd.coe.int/ViewDoc.jsp?id=267645&Site=COE
The future face of the European Pharmacopoeia: February 2001. How will recent scientific and technological developments in pharmaceutical analysis affect the ...

BTW, as you have several examples of "mises au point", I can see that "development" does not cover all of them.

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Note added at 1 hr (2012-10-27 10:09:03 GMT)
--------------------------------------------------

mise au point can also =

perfecting

--------------------------------------------------
Note added at 1 hr (2012-10-27 10:11:07 GMT)
--------------------------------------------------

another comment

is that they are talking about perfecting/developing the techniques/methods

so perhaps

development of techniques would be better

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Note added at 1 hr (2012-10-27 10:20:35 GMT)
--------------------------------------------------

étude, conception, mise au point > research, design and development
www.proz.com › KudoZ home › French to English › Manufacturing
20 Jun 2008 – French term or phrase: étude, conception, mise au point. English translation: research, design and development. Entered by: liz askew ...

liz askew
United Kingdom
Local time: 09:24
Works in field
Native speaker of:

English
PRO pts in category: 465

2 hrs confidence:

peer agreement (net): +3

technical details (have to be sorted out/ need to be fine-tuned)

Nikki Scott-Despaigne
Local time: 10:24
Native speaker of:

English
PRO pts in category: 9

Grading comment

Thanks Nikki

Notes to answerer

Asker: Exactly, Nikki. Actually I'd provisionally written "Certain technical factors have to be considered". Maybe I'll stick to that, but (everybody) more ideas welcome.

Reference comments

8 hrs

Reference: ICH guidelines

Reference information:
Thought you might find these ICH guidelines helpful for terminology. Go to document Q2: Analytical validation.
Regards,

Reference: http://www.ich.org/products/guidelines/quality/article/quali...

Leslie D
United Kingdom
Specializes in field
Native speaker of:

French,

English

Note to reference poster

Asker: Indeed they are - thanks very much, Leslie

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Mises au point techniques

English translation: technical details (have to be sorted out/ need to be fine-tuned)

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English translation: technical details (have to be sorted out/ need to be fine-tuned)

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