XYC particles

French translation: gène de résistance XYc

17:28 May 15, 2012
English to French translations [PRO]
Medical - Biology (-tech,-chem,micro-) / Toxicologie
English term or phrase: XYC particles
Impossible de trouver la signification de "XYC particles" dans les phrases suivantes tirées d'un article sur "l’antigène nucléaire de prolifération cellulaire ou PCNA (Proliferating cell nuclear antigen" :

- There was a slight increase in PCNA labeling in the large bronchiole and terminal bronchioles with XYC particles ;
- An inhalation toxicology study was conducted in rats with XYC particles containing PS80, a component of Inhalation Powder.

Merci pour votre aide
Francois Begon
François Begon
France
Local time: 00:07
French translation:gène de résistance XYc
Explanation:
Ke "c" est en minuscule.

Exemple :
domain of VanT.
Methods: Enterococcus gallinarum BM4175 (a vancomycin-susceptible
derivative with insertional inactivation of the vanC-1 gene) was
transformed with plasmid constructs pJP1 (containing the genes
necessary for resistance, C1-XYc-T) or pJP2 (with a fragment lacking
the transmembrane region of VanT-C1-XYc-dT-). Minimal inhibitory
concentrations and analysis of accumulated peptidoglycan precursors
were performed on BM4175, BM4175/pJP1 and BM4175/pJP2 grown
in the presence of L-Ser, D-Ser or in the absence of any supplement.
Uptake of 0.1 mM [14C]-L-serine was determined in all strains over a
240 s time course.
Results: Vancomycin resistance was restored in BM4175 transformed
with pJP1(C1-XYc-T). Peptidoglycan precursors were similar
to those in BM4174 under all conditions. pJP2(C1-XYc-dT) failed to
restore resistance in BM4175. Pentapeptide[D-Ser] was detected only
when L-Ser (50 mM) was present in the growth medium. A 40%
decrease in uptake of [14C]-L-Ser at 240 s was observed in BM4175
compared to BM4174. pJP1 restored uptake of [14C]-L-Ser at 240 s in
BM4175 similar to values obtained with BM4174, whereas pJP2 did
not have any effect.
Conclusions: The results indicate that the transmembrane domain of
VanT is necessary for resistance and that it is likely to function as an LSer
transporter.
In : http://www.novexel.com/publications/nxl103/2002 ECCMID.pdf
4th European Congress of Chemotherapy and Infection Abstracts

Selected response from:

Catherine GUILLIAUMET
Local time: 00:07
Grading comment
Merci pour votre aide éclairante !
Francois Bégon
2 KudoZ points were awarded for this answer



Summary of answers provided
4nanoparticles
liz askew
4gène de résistance XYc
Catherine GUILLIAUMET
Summary of reference entries provided
anything to do with ribonucleoprotein particles?
liz askew

Discussion entries: 3





  

Answers


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5
xyc particles
nanoparticles


Explanation:
Well, how else are they going to get this PS80 into mice tissue? And this PS80 forms part of the inhalation powder.

Makes sense to me:)

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Note added at 1 hr (2012-05-15 19:06:08 GMT)
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=

nanoparticules

--------------------------------------------------
Note added at 1 hr (2012-05-15 19:07:11 GMT)
--------------------------------------------------

Transport of Poly(n-butylcyano-acrylate) nanoparticles across the ...
www.ncbi.nlm.nih.gov/pubmed/21295549
by R Rempe - 2011 - Cited by 11 - Related articles
3 Feb 2011 – In previous studies it was shown that polysorbate 80(PS80)-coated poly(n-butylcyano-acrylate) nanoparticles (PBCA-NP) are able to cross the ...
[Antiamnesic activity of nerve growth factor adsorbed on poly(butyl ...

liz askew
United Kingdom
Local time: 23:07
Native speaker of: Native in EnglishEnglish
PRO pts in category: 24
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2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
xyc particles
gène de résistance XYc


Explanation:
Ke "c" est en minuscule.

Exemple :
domain of VanT.
Methods: Enterococcus gallinarum BM4175 (a vancomycin-susceptible
derivative with insertional inactivation of the vanC-1 gene) was
transformed with plasmid constructs pJP1 (containing the genes
necessary for resistance, C1-XYc-T) or pJP2 (with a fragment lacking
the transmembrane region of VanT-C1-XYc-dT-). Minimal inhibitory
concentrations and analysis of accumulated peptidoglycan precursors
were performed on BM4175, BM4175/pJP1 and BM4175/pJP2 grown
in the presence of L-Ser, D-Ser or in the absence of any supplement.
Uptake of 0.1 mM [14C]-L-serine was determined in all strains over a
240 s time course.
Results: Vancomycin resistance was restored in BM4175 transformed
with pJP1(C1-XYc-T). Peptidoglycan precursors were similar
to those in BM4174 under all conditions. pJP2(C1-XYc-dT) failed to
restore resistance in BM4175. Pentapeptide[D-Ser] was detected only
when L-Ser (50 mM) was present in the growth medium. A 40%
decrease in uptake of [14C]-L-Ser at 240 s was observed in BM4175
compared to BM4174. pJP1 restored uptake of [14C]-L-Ser at 240 s in
BM4175 similar to values obtained with BM4174, whereas pJP2 did
not have any effect.
Conclusions: The results indicate that the transmembrane domain of
VanT is necessary for resistance and that it is likely to function as an LSer
transporter.
In : http://www.novexel.com/publications/nxl103/2002 ECCMID.pdf
4th European Congress of Chemotherapy and Infection Abstracts



Catherine GUILLIAUMET
Local time: 00:07
Specializes in field
Native speaker of: Native in FrenchFrench
PRO pts in category: 63
Grading comment
Merci pour votre aide éclairante !
Francois Bégon

Peer comments on this answer (and responses from the answerer)
neutral  liz askew: How does this relate to PS80 and Toxicology? I don't find your references give any clarification, or maybe I am being thick?
1 day 16 hrs
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Reference comments


1 hr
Reference: anything to do with ribonucleoprotein particles?

Reference information:
www.ncbi.nlm.nih.gov › NCBI › Literature
by JM Berg - 2002
Section 29.3A Ribosome Is a Ribonucleoprotein Particle (70S) Made of a ..... XYU and XYC always encode the same amino acid; XYA and XYG usually do.

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Note added at 1 hr (2012-05-15 18:32:37 GMT)
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SureChem - Document - WO/PCT - Patent No. 1990010438 ...
www.surechem.org/index.php?Action=document...
ribonucleoprotein complex with a core shell ... The envelope of retroviral particles is derived from the cell-surface membrane, and most, if not all, of the lipids in the retroviral particles are ..... + PS 80 mcg/mouse 2 injections PS 80 mcg/mouse ...

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Note added at 1 hr (2012-05-15 18:34:10 GMT)
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File Format: Microsoft Powerpoint - View as HTML
The studies leading to the deciphering of the genetic codes; ... Ribonucleoprotein particles (were later called ribosomes) were revealed to be the site of .... especially at the third bases: XYU and XYC always encode the same amino acid XYA ...

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Note added at 1 hr (2012-05-15 18:37:13 GMT)
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well, your context suggests protein coding

PCNA Gene - GeneCards | PCNA Protein | PCNA Antibody
www.genecards.org/cgi-bin/carddisp.pl?gene=PCNA
Complete information for PCNA gene (protein-coding), proliferating cell nuclear antigen.

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Note added at 1 hr (2012-05-15 18:37:22 GMT)
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I would ask the author:)

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Note added at 1 hr (2012-05-15 18:51:01 GMT)
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the only other thing I had thought of was

microparticles

injected/containing PS80

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Note added at 1 hr (2012-05-15 18:58:11 GMT)
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or even

nanoparticles

see

http://www.google.co.uk/#hl=en&gs_nf=1&pq=polysorbate 80 (ps...

my understanding is that in order for this PS80 to get into the cell tissue it needs to be in a very small format:)

Good luck!

liz askew
United Kingdom
Native speaker of: Native in EnglishEnglish
PRO pts in category: 24
Note to reference poster
Asker: Merci pour votre aide et le temps passé ! Je voulais partager les points en 2 + 2. Mais la manoeuvre n'a pas marché ! Merci encore - François Bégon

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