rescue
English translation: use it to make live virus
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| 16:49 Jun 7, 2010 |
| English language (monolingual) [PRO] Medical - Medical (general) | |||||||
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|  Selected response from: Peter Nicholson (X) Poland Local time: 21:28 | ||||||
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Answers
3 mins confidence: 
insert/introduce/ inoculate Explanation: ; ) |
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22 mins confidence:
make it become active (or alive) Explanation: I am not sure if viruses are considered living beings today but I believe the text is saying that you can chemically synthesize a virus in a lab (the variola virus in this case) and get it to become active, or "alive." I personally think this is science fiction but I may be completely outdated. ;) |
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32 mins confidence:
revive Explanation: http://www.yourdictionary.com/revive |
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2 hrs confidence:
use it to make live virus Explanation: rescue it into live virus – use it to make live virus Smallpox virus is almost extinct. Stocks of it are held only by the Americans and the Russians. This would be a good project for terrorists or totalitarian governments looking for an alternative to making nuclear weapons. In theory, it is remarkably easy. First, they synthesise a small amount of the smallpox virus DNA chemically. Then, they infect cells with another poxvirus and shortly afterwards transfect the synthetic smallpox virus DNA into the infected cells. As the infection proceeds, the poxvirus replicates its own DNA and makes new virus particles as usual. This DNA is packaged into the particles to complete the replication process. However, at the same time, the synthetic smallpox virus DNA is also recognised by the genetic system of the other poxvirus. So the synthetic smallpox virus DNA is also replicated and smallpox virus particles are made, based on the synthetic smallpox virus DNA, but using the genetic mechanisms of the other poxvirus. The newly made smallpox virus DNA is packaged into the newly made smallpox virus particles, which results in live, that is infectious, smallpox virus. Here is an introduction to the problem: http://news.bbc.co.uk/2/hi/2122619.stm Here is an article about it: http://www.plospathogens.org/article/info:doi/10.1371/journa... And here is how to do it: http://jvi.asm.org/cgi/content/full/77/13/7281 |
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3 hrs confidence:
the 'recovery' of live virus through... systhesis of viral genome Explanation: I hope this is the right context :-) The first starting point is that certain kinds of biological engineering, including making pathogens drug resistant, and recovering live viruses from transfected recombinant DNA, are technically feasible and have been so for a very long time. The recovery of polio virus from cDNA was accomplished by Baltimore and coworkers in 1982. Example sentence(s):
Reference: http://lifeboat.com/ex/great.power.great.responsibility Reference: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T... |
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22 hrs confidence:
ensure replication / facilitate generation Explanation: I believe that virus rescue is slightly more than introduction or recovery; it is a process whereas virus replication/generation is facilitated. A few examples for the use of the term in context: "... to ensure that the generated recombinant viruses were able to replicate. (...) system can be used for the generation of high yields of influenza B virus" http://www.pnas.org/content/99/17/11411.full "This plasmid-based reverse genetics technique facilitates the generation of recombinant influenza viruses containing specific mutations in their genes." http://www.ncbi.nlm.nih.gov/pubmed/10516084 "... we use a plasmid–only rescue system that allows the rapid generation of high–yield recombinant vaccine strains." http://rstb.royalsocietypublishing.org/content/356/1416/1965... |
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