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surrogate endpoint

Lithuanian translation: tarpinis/surogatinis rezultatas/išvada

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:surrogate endpoint
Lithuanian translation:tarpinis/surogatinis rezultatas/išvada
Entered by: vita_translates

21:07 Mar 15, 2010
English to Lithuanian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: surrogate endpoint
"It was noted that the analysis, based on the determination of colistin sulfate concentration in the gastrointestinal tract after different levels of exposure and minimum inhibitory concentrations (MIC) data from E. coli strains collected in five European countries could be questioned as the surrogate endpoint Cmax/MIC was not validated for local exposure in the gastrointestinal tract and the fraction of active compound bound to the faecal content was not known."

Gal "pakaitinis galutinis taškas"?. Taip pat nelabai suprantu sakinio dalį "surrogate endpoint Cmax/MIC was not validated for local exposure in the gastrointestinal tract". Ar reikia suprasti taip: vietinio poveikio virškinimo trakte pakaitinis galutinis taškas Cmax/MIC nebuvo patvirtintas?
Silvernight
Lithuania
Local time: 02:42
tarpinis/surogatinis rezultatas/išvada
Explanation:
Endpoint- tai klinikinio tyrimo "galutinis taškas", kas tiksliau būtų laukiamas rezultatas, kriterijus, pagal kurį įvertinamas terapijos poveikis ligos eigai
'Surrogate Endpoint" sinonimai yra "intermediary outcomes, surrogate outcomes"

Štai apibrėžimas:

Surrogate endpoints

Outcome measures that are not of direct practical importance but are believed to reflect outcomes that are important; for example, blood pressure is not directly important to patients but it is often used as an outcome in clinical trials because it is a risk factor for stroke and heart attacks. Surrogate endpoints are often physiological or biochemical markers that can be relatively quickly and easily measured, and that are taken as being predictive of important clinical outcomes. They are often used when observation of clinical outcomes requires long follow-up. (Also called intermediary outcomes, surrogate outcomes.)
Selected response from:

vita_translates
Lithuania
Local time: 02:42
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3pakaitinis galutinis taškas
Leonardas
3tarpinis/surogatinis rezultatas/išvada
vita_translates
2surogatinis žymuo
Kristina Radziulyte


  

Answers


10 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
pakaitinis galutinis taškas


Explanation:
was not validated - čia geriau: nebuvo patikrintas

Leonardas
Local time: 02:42
PRO pts in category: 122
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19 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5
surogatinis žymuo


Explanation:
"surrogate endpoint" dar vadinamas "surrogate marker".
http://en.wikipedia.org/wiki/Surrogate_endpoint

--------------------------------------------------
Note added at 22 mins (2010-03-15 21:29:30 GMT)
--------------------------------------------------

dar "pakaitinis žymuo" http://www.google.lt/search?hl=lt&q=pakaitinių žymenų&meta=&...

Example sentence(s):
  • Tiriant naujas vakcinas dažnai taikoma tokia praktika, kai skiepų veiksmingumas vertinamas pagal vadinamuosius surogatinius žymenis.
  • ...plazmos viruso krūvis (viremijos lygmuo) tiesiogiai atspindi bendrą viruso krūvį ir yra patikimas surogatinis žymuo bendram ŽIV kiekiui matuoti.

    Reference: http://www.gimdoskakleliovezys.lt/info_20070401.htm
    Reference: http://www.medicine.lt/index.php?pagrid=leidiniai&strid=6507...
Kristina Radziulyte
Lithuania
Local time: 02:42
Works in field
Native speaker of: Lithuanian
PRO pts in category: 4
Login to enter a peer comment (or grade)

10 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
tarpinis/surogatinis rezultatas/išvada


Explanation:
Endpoint- tai klinikinio tyrimo "galutinis taškas", kas tiksliau būtų laukiamas rezultatas, kriterijus, pagal kurį įvertinamas terapijos poveikis ligos eigai
'Surrogate Endpoint" sinonimai yra "intermediary outcomes, surrogate outcomes"

Štai apibrėžimas:

Surrogate endpoints

Outcome measures that are not of direct practical importance but are believed to reflect outcomes that are important; for example, blood pressure is not directly important to patients but it is often used as an outcome in clinical trials because it is a risk factor for stroke and heart attacks. Surrogate endpoints are often physiological or biochemical markers that can be relatively quickly and easily measured, and that are taken as being predictive of important clinical outcomes. They are often used when observation of clinical outcomes requires long follow-up. (Also called intermediary outcomes, surrogate outcomes.)



    Reference: http://www.support-collaboration.org/summaries/s.htm
vita_translates
Lithuania
Local time: 02:42
Native speaker of: Lithuanian
PRO pts in category: 28

Peer comments on this answer (and responses from the answerer)
neutral  Vita Juciuviene: taip, bet tarp jų turi būti kablelis arba „ir“(arba). „Galutinis taškas“ irgi išskirtas ne lietuviškom kabutėm.
10 days
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