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  3. Medical: Pharmaceuticals

drug-drug interaction studies with

German translation: Studien zu Arzneimittel-Wechselwirkungen

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:drug-drug interaction studies
German translation:Studien zu Arzneimittel-Wechselwirkungen
Entered by: Simon Kramer

17:05 Aug 17, 2009
English to German translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: drug-drug interaction studies with
Präsentation über klinische Outcomes


Clinical Pharmacology Summary

Drug interaction studies with laropiprant
- No clinically meaningful effect on warfarin and digoxin
- No effect on rosiglitazone (CYP2C8 substrate)
- No significant alteration of plasma levels from oral contraceptives containing ethinyl estradiol
- No effect on midazolam PK (CYP3A4 substrate)
- Laropiprant is an inhibitor of UGT2B4 and UGT2B7
- Clarithromycin (strong CYP3A4 inhibitor) does not alter laropiprant PK to a clinically meaningful degree

***Drug-drug interaction studies with*** ER niacin/laropiprant
- Modest increase in simvastatin acid (AUC 60%, Cmax 40%) attributed to ER niacin
Special populations
- Renal insufficiency (severe CrCl < 30 mL/min/1.73 m2)
-- Modest (not clinically significant) effect on laropiprant AUC
- Moderate hepatic insufficiency
-- Has a significant impact on laropiprant pharmacokinetics, 3-fold increase in laropiprant AUC
-- As with other niacin products, ER niacin/laropiprant is contraindicated in patients with significant hepatic dysfunction

Ich steh hier grad vollkommen auf dem Schlauch und komm nicht mehr weiter. Wie heissen diese "drug-drug interaction studies" auf Deutsch, bzw. wie muss ich diesen Satz formulieren.

Ich bin dankbar um jeden neuen Ansatz, der mir dabei helfen kann, meinen Knoten zu lösen.

MTIA
Simon Kramer
Italy
Local time: 02:16
Studien zu Arzneimittel-Wechselwirkungen
Explanation:

oder: zu Arzneimittelinteraktionen

cf.: "Arzneimittelinteraktionen
synonym: IA, Arzneimittel-Wechselwirkungen, Drug-Drug-Interactions, DDI"
Selected response from:

Johanna Timm, PhD
Canada
Local time: 17:16
Grading comment
Besten Danke, Johanna!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +11Studien zu Arzneimittel-Wechselwirkungen
Johanna Timm, PhD
5 +1Studien zu Arzneimittelwechselwirkungen mit
Blaess
3Pharmazeutika-Interaktionssudie
Rolf Keiser


  

Answers


10 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
Pharmazeutika-Interaktionssudie


Explanation:
Studie über die Reaktion/Auswirkungen verschiedener Medikamente untereinander (Nebenwirkungen)

Rolf Keiser
Switzerland
Local time: 02:16
Native speaker of: Native in EnglishEnglish, Native in GermanGerman
PRO pts in category: 12
Login to enter a peer comment (or grade)

10 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +11
Studien zu Arzneimittel-Wechselwirkungen


Explanation:

oder: zu Arzneimittelinteraktionen

cf.: "Arzneimittelinteraktionen
synonym: IA, Arzneimittel-Wechselwirkungen, Drug-Drug-Interactions, DDI"


    Reference: http://www.pharmawiki.ch/wiki/index.php?wiki=Interaktionen
Johanna Timm, PhD
Canada
Local time: 17:16
Native speaker of: Native in GermanGerman
PRO pts in category: 47
Grading comment
Besten Danke, Johanna!

Peer comments on this answer (and responses from the answerer)
agree  Susanne Schiewe
4 mins
agree  Cornelia Mayer
8 mins
agree  CarenIsabel
9 mins
agree  Marga Shaw
24 mins
agree  Klaus Urban
32 mins
agree  Hildegard Klein-Bodenheimer (X): Wechselwirkungen
32 mins
agree  Steffen Walter
1 hr
agree  DDM
2 hrs
agree  Ruth Wöhlk
4 hrs
agree  Dr. Anja Masselli
14 hrs
agree  robin25
1 day 23 hrs
Login to enter a peer comment (or grade)

14 mins   confidence: Answerer confidence 5/5 peer agreement (net): +1
Studien zu Arzneimittelwechselwirkungen mit


Explanation:
Arzneimittelwechselwirkungen (auch Interaktionen) können bei gleichzeitiger Einnahme verschiedener Arzneimittel auftreten. Die erwünschte Wirkung kann dadurch verstärkt, abgeschwächt oder aufgehoben werden. Zusätzlich können unerwünschte Arzneimittelwirkungen ("Nebenwirkungen") auftreten.



    Reference: http://de.wikipedia.org/wiki/Arzneimittelwechselwirkung
Blaess
Germany
Local time: 02:16
Works in field
Native speaker of: Native in GermanGerman

Peer comments on this answer (and responses from the answerer)
agree  Harald Moelzer (medical-translator): ...ja, in einem Wort...
6 days
  -> Danke!
Login to enter a peer comment (or grade)



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