mean fold changes

23:20 Jul 14, 2009
This question was closed without grading. Reason: Other

English to Portuguese translations [PRO]
Medical - Medical (general)
English term or phrase: mean fold changes
The elevated ALT values in this study did not reach the high levels that were reported in the previous study in which the drug was administered orally to elderly subjects. Mean changes, individual plots and mean fold changes are illustrated in the figure below.
CicaBarth
Local time: 14:35


Summary of answers provided
5alterações no aumento médio
Christina Paiva
3média de enovelamentos alterados
Luiza Modesto


Discussion entries: 12





  

Answers


4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
média de enovelamentos alterados


Explanation:
Penso que esse fold pode ser de "protein folding", ou seja, como uma proteína se "enrola" (enovela).

Algumas proteínas ao serem sintetizadas necessitam do auxílio de chaperones moleculares para seu correto enovelamento.

Some newly synthesized proteins require the assistance of molecular chaperones for their correct folding.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415...

Ainda assim, com todo esse cuidado de assegurar que a seqüência de aminoácidos esteja correta, ainda é possível que uma proteína não consiga desempenhar suas funções por erro no enovelamento.
http://pt.wikipedia.org/wiki/Chaperona

For many proteins the correct three dimensional structure is essential to function.[3] Failure to fold into the intended shape usually produces inactive proteins with different properties including toxic prions.
http://en.wikipedia.org/wiki/Protein_folding

Ou será média de alterações no enovelamento? Pelo que lembro de biologia, as duas sugestões são possíveis mas a acima é mais provável.

Veja no seu contexto se é isso mesmo.

Luiza Modesto
Brazil
Local time: 14:35
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in PortuguesePortuguese
PRO pts in category: 199
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1 day 23 hrs   confidence: Answerer confidence 5/5
alterações no aumento médio


Explanation:
O termo é muito usado em bioquímica. No seu texto literalmente: em quantas vezes os valores da atividade da enzima ALT (Alanine Aminotransferase) foi alterada (aumentada) em razão do tratamento.

Michaellis:
suf formador de adjetivos e advérbios multiplicativos:
twofold duplo ou duas vezes mais,
tenfold décuplo ou dez vezes mais.
manifold múltiplo, multíplice, multiforme.


Random House
-fold,
a native English suffix meaning “of so many parts,” or denoting multiplication by the number indicated by the stem or word to which the suffix is attached: twofold; manifold.

Hope I'm not too late

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Note added at 4 days (2009-07-19 03:21:50 GMT)
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You're welcome :) eu vivo brigando com este termo ... nunca se encaixa em PT se vc não mudar a frase inteira...

Christina Paiva
Brazil
Local time: 14:35
Specializes in field
Native speaker of: Native in PortuguesePortuguese, Native in EnglishEnglish
PRO pts in category: 68
Notes to answerer
Asker: Muito obrigada, Christina! A tempo!

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