substrate inhibition

16:56 Apr 30, 2007 

Investigado con otros especialistas del área q me confirman que es "inhibición por sustrato. Cierro la pregunta. Gracias a todos.

06:35 Apr 30, 2007 

Voy a investigar más a fondo hoy con un bioquímico. Gracias por llamar mi atención Claudia.

01:11 Apr 30, 2007 

tu opción está equivicada, esa es mi opinión

01:07 Apr 30, 2007 

substrate is reduced by inhibiting the enzime than forms the substrate. That makes more sense to me. What is inhibited is the production of substrate not the substrate.

01:03 Apr 30, 2007 

Irina, I followed your link and I was right. I paste: [["This inhibitor, now known as miglustat, is directed against the enzyme that transfers glucose to ceramide forming glucosylceramide (glucocerebroside = substrate).]] So the production of the

23:19 Apr 29, 2007 

Inhibición por sustrato

23:06 Apr 29, 2007 

Claudia: this is an experimental treatment for Gaucher disease. See this reference:
http://www.ijhg.com/article.asp?issn=0971-6866;year=2005;vol...
"Administering a Substrate Inhibitor
Although low molecular weight inhibitors of glucocerebrosidase are undoubtedly inexpensive to synthesize, miglustat is being sold at a high price. Consequently, little saving can be achieved by using these potentially less expensive treatment modalities. If the price of inhibitors were lowered substantially they might prove an excellent alternative to enzyme replacement therapy in some patients. But at present, they are as costly as enzyme replacement when the appropriate low dose therapy regimen is given. It is notable in this regard that while the dose of enzyme usually given in some Western countries is much higher than is needed, reducing the dose of miglustat has been shown to severely impair its effectiveness."

22:08 Apr 29, 2007 

colour or other ways of measuring concentration, so you can inhibit the substance that will act over the substrate to change it or inhibit the substance that will allow you to measure conc. but how can you inhibit the substrate???

22:05 Apr 29, 2007 

Hi Irina, I am suspicious of the way it has been written, the substrate is the substance that will be changed within the reaction, for example by and enzime. Then if you are measuring something , you will either add something else to show change of

15:32 Apr 29, 2007 

"substrate inhibitors" would be more like it. Thanks in advance!